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HomeMy WebLinkAboutDEQ-CFW_00001477A T O X I C- F R E E LEGACY C O A L I T I O N F A C T S H E E T September 2005 What are Perfluorinated Compounds? Perfluorinated compounds (PFCs) are chemicals used in a variety of products to prevent stains, keep liquids from penetrating fabrics and papers, and prevent sticking. PFCs are found in products like non-stick pans, cloth- ing, furniture, packaged food containers, and many others. PFCs are so -named because they contain large amounts of the element fluorine, though not in the more familiar form of fluoride used in toothpaste. PFCs include a whole range of compounds, including the chemicals added to products, chemicals used to produce these additives, and breakdown products that can be formed later. One of the chemicals of greatest concern is perfluorooctanoic acid, called PFOA or C8. How are PFCs Used? Typically, PFCs are bonded to the products mentioned above to form a barrier that makes the products imper- meable or slippery. Some well-known trade names include Teflon, Stainmaster, Scotchgard, and others. Why Should I be Concerned? PFOA is produced in the manufacturing process and also can be a breakdown product of PFCs, for example if non-stick pans are allowed to reach temperatures in excess of 500 degrees. If PFOA is ingested or inhaled, it remains in the body for many years. It would take more than four years for the body to clear half of the PFOA if no further exposure occurred, but since PFCs are still being produced, levels continue to rise (Burris, 2002). Workers who are exposed to PFOA on the job have high levels in their body, in some cases close to levels that produced toxic effects in laboratory animals. Testing has also shown PFOA and 14 other PFCs in the bodies of the general population, especially in children (3M, 2002; 3M, 2001). This contamination may be coming from exposure to household products contain- ing PFCs, as well as by ingesting or inhaling PFOA in the environment. PFOA is a widespread pollutant, and scientists are beginning to understand how it spreads from factories and other sources to every part of the world. PFOA can cause a variety of health effects. Some children have levels of PFOA and other PFCs in their blood higher than those that caused changes in organ weights in lab animals (3M, 2001). PFOA also causes cancer, including cancers of the testes, breast, liver, and pancreas (EPA, 2002; Sibinski, 1987). PFOA has also been linked to hypothyroidism, decreased growth, effects on the pituitary gland, changes in hormone levels, and effects on the immune system and on repro- duction (Butenhoff, 2002; DuPont, 2002a; DuPont, 2002b; DuPont, 2002c; DuPont, 2002d; DuPont, 2002e; DuPont, 2002f; Yang, 2001; York, 2002; Sibinski, 1987; Goldenthal, 1978). Although some of these effects occur at levels higher than those currently found in humans, because PFCs are still produced and are still breaking down, human exposures will continue to rise, and would rise to some extent even if PFCs were banned today. What Should Government and Industry Do? ❖ Governments should phase out the use of PFOA and other PFCs that persist in the environment and accumulate in our bodies and the environ- ment. Sweden announced plans this summer to move forward with a proposed ban on PFOA. •••• Governments should require rigorous safety tests before chemicals are used in products and restrict the use of those chemicals that fail the tests. ❖ Industry must stop manufacturing and using PFOA and other PFCs that persist in the environment and build up in our bodies. ❖ Industry should develop safe products to meet consumer needs without threatening our health or the environment. ❖ Manufacturers must tell consumers whether a product they sell contains PFCs. DEQ-CFW 00001477 What Can I Do? Avoid purchasing or limit your use of products containing PFCs. Examples of products containing PFCs include: ❖ Teflon or non-stick cookware. If you choose to continue using non-stick cookware, be very careful not to let it overheat . Do not fry at high temperature or leave cookware unattended on the stove. Do not put non-stick cookware under the broiler. ❖ Furniture or carpets marketed as "stain -resistant." ❖ Clothing that has been treated for water and stain resistance because many of these coatings contain PFCs. ❖ Packaged foods, including greasy fast foods and microwave popcorn bags. Many food packages are treated with PFCs to keep grease from soaking through the packages ❖ Cosmetics containing ingredients that include the works "fluoro" or "perfluoro." While it makes sense to avoid unnecessary use of any products containing dangerous chemicals, too often it is difficult to find out what chemicals are in a particular product and whether they are dangerous. The burden shouldn't fall on consumers to determine whether a product they buy is hazardous to their health. Manu- facturers and governments are in the best position to ensure the products they sell and regulate aren't harming our health. Support government phaseouts on PFCs by speaking out, writing letters to elected officials, govern- ment agencies, and manufacturers, and getting involved with groups working to eliminate the worst chemicals. References Burris, J.M., J.K. Lundberg, G. Olsen, C. Simpson, and J. Mandel. 2002. Determination of serum half-lives of several fluorochemicals: Interim Report #2. Study Sponsor: 3M Company, Corporate Occupational Medicine Department, U.S. EPA AR226-1086. 3M. 2001. TSCA 8(e) supplemental notice for sulfonate-based and carboxycylic- based fluorochemicals -Docket numbers 8EHQ 1180-373; 8EHQ 1180-374; 8EHQ 0381-0394; 8EHQ 05980373. U.S. EPA Administrative Record AR226- 1019. 3M. 2002. Analysis of pooled human sera and plasma and monkey sera for fluorocarbons using exygen method ExM-023-071. Report prepared for 3M, St. Paul, MN by Exygen Research, State College, PA. Sponsor study number E02- 1071; Exygen Study Number: 023-082 U.S. EPA Administrative Record AR226- 1152. Sibinski, LJ. 1987. Two -Year oral (diet) toxicity/carcinogenicity study of fluorochemical FC-143 (perfluorooctane ammonium carboxylate) in rats. Report prepared for 3M, St. Paul, Minnesota by Riker Laboratories Inc. Study No. 0281CR0012; 8EHQ 1087-0394, October 16, 1987 Reviewed in US EPA "Revised Draft PFOA Hazard Assessment -Robust Study Annex" AR226-1137, p. 260-267. Butenhoff, J., G. Costa, C. Elcombe, D. Farrar, K. Hansen, H. Iwai, R. Jung, G. Kennedy Jr., P. Lieder, G. Olsen, and P. Thomford. 2002. Toxicity of Ammonium Perfluorooctanoate in Male Cynomolgus Monkeys after Oral Dosing for 6 Months. Toxicol Sci 690): 244-257. Also reviewed in US EPA Reviewed in US EPA "Revised Draft PFOA Hazard Assessment -Robust Study Annex" AR226-1137, p. 244-253. DuPont Haskell Laboratory. 2002. Developmental and one -generation reproduction study: Mixture of poly(difluoro-methylene), alpha-fluoro-omega [2-(phosphonooxy) ethyl]-, monoammonium salt (CAS# 65530-71-4); poly(difluoro-methylene), alpha- fluoro-omega[2-(phosphonooxy) ethyl]-, diammonium salt (CAS# 65530-72-5); poly(difluoromethylene), alpha, alpha- [phosphinicobis(oxy-2,1-ethanediyl)bis [omega-fluoro-1, ammonium salt (CAS# 65530-70-3); isopropyl alcohol (CAS# 67- 63-0); and water (CAS# 7732-18-5). US Environmental Protection Agency: Toxic Substance Control Act (TSCA) Section 8(e) Submission Received from 01 /02/03 to 1/15103: 8EHQ 1202-15247A. December 20, 2002. Available online at http:// wv,rw.epa.gov/opptintr/tsc-a8e/doc/new8c.htm. DuPont Haskell Laboratory. 2002. Subchronic toxicity study; Mixture of poly(difluoro-methylene), alpha-fluoro-omega [2-(phosphonooxy) ethyl]-, monoammonium salt (CAS# 65530-71-4); poly(difluoro-methylene), alpha-fluoro- omega[2-(phosphonooxy) ethyl]-, diammonium salt (CAS# 65530-72-5); poly(difluoromethylene), alpha, alpha- [phosphinicobis(oxy-2,1-ethanediyl)bis [omega-fluoro-], ammonium salt (CAS# 65530-70-3); isopropyl alcohol (CAS# 67- 63-0); and water (CAS# 7732-18-5) (Telomer B Phoshate). US Environmental Protection Agency: Toxic Substance Control Act (TSCA) Section 8(e) Submission Received from 02/27/02 thru 03/ 13/02: 8EHQ 0202-15072A. February 6, 2002. Available online at http://www.epa.gov/oppt/tsca8e/doc/8esub/8eO3l3O2.htm. DuPont. 2002. The updated copy of DuPont Product Stewardship on December 17, 2001. U.S. EPA Administrative Record AR226-1069. DuPont Haskell Laboratory. 2002. Results of an oral gavage combined 90-day repeated dose and one -generation reproductive toxicity study in rats for poly (oxy- 1,2-ethanediyl) alpha-hydro-omega-hydroxy- ether, with alpha-fluoro- omega (2- hydroxyethyl) poly (difluoromethane) (1:1) (telomer B monoether)(CAS Number 65545-80-4; non-HPV). US Environmental Protection Agency: Toxic Substance Control Act (TSCA) Section 8(e) Submission Received from 10/15/01 thru 12/07/ 01: 8EHQ 1001-14915. November 5, 2001. Available online at http:// www.epa.gov/opptintr/tsca8e/doc/8esub/8cl 0150 Lhtm. DuPont. 2002. DuPont flurotelomer product stewardship update, presented November 25, 2002. U.S. EPA Administrative Record AR226-1147. DuPont Haskell Laboratory. 2002. Results of a 2-week inhalation toxicity study in rats for n-diiodoperfluoro-alkanes mixture (no CAS); hexadecafluoro-1,8- diiodooctane (CAS 335-70-6); 1,1,2,2,3,3,4,4-octafluoro-1,4-diiodobutane (CAS 375-50-8); 1,6-diiodo-perfluorohexane (375-80-4); diiodofluoro chemical Q) (CAS Number 65975-18-0); non-HPV chemicals. US Environmental Protection Agency: Toxic Substance Control Act (TSCA) Section 8(e) Submission Received from 5/9/02 thru 5/22/02: 8EHQ 0502-13829D. May 7,2002. Available online at http:// www.epa.gov/oppt/tsca8e/doc/8esub/2002/0509_052202.htm. Environmental Protection Agency (EPA). 2002. Revised draft hazard assessment of perfluorooctanoic acid and its salts, November 4, 2002. U.S. EPA Administrative Record AR226-1136. York, R.G. (2002). Oral (gavage) two -generation (one litter per generation) reproduction study of ammonium perfluorooctanoate (APFO) in rats. Report prepared for 3M, St. Paul, MN by Argus Research (Horsham, PA). Sponsor's Study No. T-6889.6., Reviewed in U.S. EPAAR226-1092. Goldenthal, E.I., D.C. Jessup, R.G. Geil, and J.S. Mehring. 1978. Ninety -day subacute rhesus monkey toxicity study: Fluorad " Fluorochemical FC-143. Report prepared for 3M, St. Paul, MN by Institutional Research and Development Corporation (Mattawan, MN). Study No. 137-090. Reviewed in US EPA "Draft PFOA Hazard Assessment" AR226-1079. Yang, Q, Y. Xie, A.M. Eriksson, B.D. Nelson, and J.W. DePierre. 2001. Further evidence for the involvement of inhibition of cell proliferation and development in thymic and splenic atrophy induced by the peroxisome proliferator perfluoroctanoic acid in mice. Biochem Pharmacol 62(8): 1133-40. DEQ-CFW 00001478