DEQ-CFW_00000331

As of July 17, 2017
This calculation workbook was created by C. Ventaloro
June 13, 2017 - The calculation on the DHHS Original tab was created using the,exposure factor, toxicity endpoint, and calculation information supplied by
Department of Health and Human Services (DHHS) staff via email communications with C. Brower. The calculation on this tab results in the same final
concentration (70,909 ng/L) that DHHS staff issued as a health advisory on June 13, 2017. Updated by C. Ventaloro.
June 13, 2017 - The toxicity information provided on 6/13/2017 was applied to the Groundwater Standards calculation (per 15A NCAC 02L) onn the NC
Calcs tab to determine what impact the inclusion of a releative source contributution would have on the final concentration. This was done solely for
informational purposes. The situation in the Cape Fear River does not currently involve the contamination of groundwater drinking sources. Updated by C.
Ventaloro

DHHS calculated concentration for GenX Der email to C. Brower dated June 13, 2017
Exposure factors
Body weight = 7.8 1 kg
Dose (mg/kg/day) = [(Conc (mg/L) x Intake (L/day))/Body weight (kg)]
Drinking water intake = 1.1 L/day intake
For concentration,
Based on ATSDR exposure factors for bottle fed infants
Conc (mg/L) = [(Dose (mg/kg/day) x Body weight (kg))/Intake (L/day)]
Concentration = 0.070909 mg/L DHHS issued a health advisory
Toxicity endpoint
Derived No Effect Level = 0.01 mg/kg/day
Based on 2-year study in rats, oral route exposure obtained from
70.90909 ug/L for GenX of 70,909 ng/L on June
V
European Chemical Registration
70909.09 ng/L 13, 2017