WI0800040_Correspondence_19980227

02/27/98 FRI 15:29 FAX
Naval Facilities Engineering Service Center
1100 23rd Ave.
Port Hueneme, CA 93043-4370
Fax Cover Sheet
DATE: February 27, 1998 TIME: 3:30 PM
TO: Marcus Geist PHONE: [phone]
NC DEHNR, DWQ,GW Section FAX: [phone]
FROM: Laura Yeh PHONE: [phone]
NFESC, ESC 411 FAX: [phone]
RE: Varsol info
Number of pages including cover sheet: 12
Message
Marcus,
Here is some information on Varsol. I have attached the MSDS for Varsol 1
as well as some entries for Varsol out of the Merck Index and Hawley's The
Condensed Chemical Dictionary.
Let me know if you have any questions!
Laura
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02/27/98 FRI 15:30 FAX
Aug '1997 rt #:,.4.6
MATERIAL SAFETY DATA SHEET
EXXON CHEMICAL COMPANY
A Division of EXXON CORPORATION
E j002
Page 2 oT zz
PAGE: 1
DATE PREPARED: MAY 31, 1997
MSDS NO.: 92890627
VARSOL 1 SOLVENT
SECTION 1 CHEMICAL PRODUCT AND COMPANY IDENTIFICATION
PRODUCT NAME: VARSOL 1 SOLVENT
CHEMICAL NAME:
Not Applicable: Blend
CHEMICAL FAMILY:
Petroleum Hydrocarbon
PRODUCT DESCRIPTION:
Clear colorless liquid with a petroleum odor.
CONTACT ADDRESS:
EXXON CHEMICAL COMPANY
P.O. BOX 3272, HOUSTON, TEXAS 77253-3272
**
**
**
EMERGENCY TELEPHONE NUMBERS: (24 Hours)
CHEMTREC [phone]
EXXON CHEMICAL COMPANY [phone]
6052-41-3
NON EMERGENCY TELEPHONE NUMBERS : (8am-5pm M-F)
FOR HEALTH AND SAFETY INFORMATION CALL : [phone]
FOR GENERAL PRODUCT INFORMATION CALL : [phone]
SECTION 2 COMPOSITION/INFORMATION ON INGREDIENTS
The composition of this mixture may be proprietary information. In the event
of a medical emergency, compositional information will be provided to a
physician or nurse.
This product is hazardous as defined in 29 CFR1910.1200, based on the
following compositional information:
OSHA HAZARD COMPONENT
Combustible Petroleum hydrocarbons
OSHA PEL; ACGIH TLV Stoddard Solvent
OSHA PEL; ACGIH TLV Trimethylbenzene
SECTION 3 HAZARDS IDENTIFICATION
POTENTIAL HEALTH EFFECTS
EYE CONTACT:
Slightly irritating but does not injure eye tissue.
SKIN CONTACT:
Frequent or prolonged contact may irritate and cause dermatitis.
Low order of toxicity.
Skin contact may aggravate an existing dermatitis condition.
INHALATION:
High vapor/aerosol concentrations (greater than approximately 1000
ppm)
Continues on page 2
1

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1 Aug 1997 16:46
VARSOL 1 SOLVENT
C_j 0 0 3
Page :3 or ee
MATERIAL SAFETY DATA SHEET
EXXON CHEMICAL COMPANY
A Division of EXXON CORPORATION
PAGE: 2
DATE PREPARED: MAY 31, 1997
MSDS NO.: 92890627
are irritating to the eyes and the respiratory tract, may cause headaches,
dizziness, anesthesia, drowsiness, unconsciousness, and other central
nervous system effects, including death.
INGESTION:
Small amounts of this product aspirated into the respiratory system during
ingestion or vomiting may cause mild to severe pulmonary injury, possibly
progressing to death.
Minimal toxicity.
SECTION 4 FIRST AID MEASURES
EYE CONTACT:
Flush eyes with large amounts of water until irritation subsides. If
irritation persists, get medical attention.
SKIN CONTACT:
Flush with large amounts of water; use soap if available.
Remove grossly contaminated clothing, including shoes, and launder before
reuse.
INHALATION:
Using proper respiratory protection, immediately remove the affected
victim from exposure. Administer artificial respiration if breathing
is stopped. Keep at rest. Dail for prompt medical attention.
INGESTION:
If swallowed, DO NOT induce vomiting. Keep at rest. Get prompt medical
attention.
SECTION 5 FIRE -FIGHTING MEASURES
FLASHPOINT: 104 Deg F. METHOD: TCC NOTE: Minimum
FLAMMABLE LIMITS: LEL: 2.1 UEL: 13.3 0 77 Deg F. NOTE: Approximate
AUTOIGNITION TEMP.: 490 Deg F. NOTE: Approximate
GENERAL HAZARD
Combustible Liquid, can form combustible mixtures at temperatures at
or above the flashpoint.
Static Discharge, material can accumulate static charges which can cause
an incendiary electrical discharge .
"Empty" containers retain product residue (liquid and/or vapor) and can be
dangerous. DO NOT pressurize, cut, weld, braze, solder, drill, grind, or
expose such containers to heat, flame, sparks, static electricity, or
other sources of ignition; THEY MAY EXPLODE AND CAUSE INJURY OR DEATH.
Empty drums should be completely drained, properly bunged and promptly re-
turned to a drum reconditioner, or properly disposed of.
FIRE FIGHTING
Use water spray to cool fire exposed surfaces and to protect personnel.
Isolate "fuel" supply from fire.
Use foam, dry chemical, or water spray to extinguish fire.
Continues on page 3

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MATERIAL SAFETY DATA SHEET
EXXON CHEMICAL COMPANY
A Division of EXXON CORPORATION
PAGE: 3
DATE PREPARED: MAY 31, 1997
MSDS NO.: 92890627
VARSOL 1 SOLVENT
Avoid spraying water directly into storage containers due to danger of
boilover.
This liquid is volatile and gives off invisible vapors. Either the liquid
or vapor may settle in low areas or travel some distance along the ground
or surface to ignition sources where they may ignite or explode.
DECOMPOSITION PRODUCTS UNDER FIRE CONDITIONS
No unusual
SECTION 6 ACCIDENTAL RELEASE MEASURES
LAND SPILL
Eliminate sources of ignition. Prevent additional discharge of material,
if possible to do so without hazard. For small spills implement cleanup
procedures; for large spills implement cleanup procedures and, if in
public area, keep public away and advise authorities. Also, if this
product is subject to CERCLA reporting (see Section 15 REGULATORY
INFORMATION) notify the National Response Center.
Prevent liquid from entering sewers, watercourses, or low areas. Contain
spilled liquid with sand or earth. Do not use combustible materials such
as sawdust.
Recover by pumping (use an explosion proof or hand pump) or with a
suitable absorbent.
Consult an expert on disposal of recovered material and ensure
conformity to local disposal regulations.
WATER SPILL
Eliminate sources of ignition. Warn occupants and shipping in surrounding
and downwind areas of fire and explosion hazard and request all to stay
clear.
Remove from surface by skimming or with suitable adsorbents. If allowed
by local authorities and environmental agencies, sinking and/or
suitable dispersants may be used in non -confined waters.
Consult an expert on disposal of recovered material and ensure
conformity to local disposal regulations.
SECTION 7 STORAGE AND HANDLING
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VARSOL 1 SOLVENT
MATERIAL SAFETY DATA SHEET
EXXON CHEMICAL COMPANY
A Division of EXXON CORPORATION
PAGE: 4
DATE PREPARED: MAY 31, 1997
MSDS NO.: 92890627
ELECTROSTATIC ACCUMULATION HAZARD:
Yes, use proper grounding procedure.
Additional information regarding safe handling of products with static
accumulation potential can be ordered by contacting the American Petroleum
Institute (API) for API Recommended Practice 2003, entitled "Protection
Against Ignitions Arising Out of Static, Lighting, and Stray Currents"
(American Petroleum Institute, 1220 L Street Northwest, Washington, DC
20005), or the National Fire Protection Association (NFPA) for NFPA 77
entitled "Static Electricity" (National Fire Protection Association,
1 Batterymaroh Park, P.O. Box 9101, Quincy, MA 02269-9101).
STORAGE TEMPERATURE, Deg F:
Ambient
LOADING/UNLOADING TEMPERATURE, Deg F:
Ambient
STORAGE/TRANSPORT PRESSURE, mmHg:
Atmospheric
LOADING/UNLOADING VISCOSITY, cSt:
1.2
STORAGE AND HANDLING:
Keep container closed. Handle and open containers with care.
Store in a cool, well ventilated place away from incompatible materials.
Do NOT handle or store near an open flame, heat or other sources of
ignition. Protect material from direct sunlight.
Material will accumulate static charges which may cause an electrical
spark (ignition source). Use proper grounding procedures.
Do NOT pressurize, cut, heat, or weld containers. Empty product
containers may contain product residue. Do NOT reuse empty containers
without commercial cleaning or reconditioning.
SECTION 8 EXPOSURE CONTROLS/PERSONAL PROTECTION
EXPOSURE CONTROLS
The use of local exhaust ventilation is recommended to control process
emissions near the source. Laboratory samples should be
handled in a lab hood. Provide mechanical ventilation of confined spaces.
See respiratory protection recommendations.
PERSONAL PROTECTION
For open systems where contact is likely, wear safety glasses with side
shields, long sleeves, and chemical resistant gloves.
Where contact may occur, wear safety glasses with side shields.
Where concentrations in air may exceed the limits given in this
Section and engineering, work practice or other means of exposure
reduction are not adequate, NIOSH/MSHA approved respirators may
be necessary to prevent overexposure by inhalation.
Continues on page 5

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1 Aug 1997 16:48
VARSOL 1 SOLVENT
2006
Page 6 of 22
MATERIAL SAFETY DATA SHEET
EXXON CHEMICAL COMPANY
A Division of EXXON CORPORATION
PAGE:
DATE PREPARED:
MSDS NO.:
5
MAY 31, 1997
92890627
WORKPLACE EXPOSURE GUIDELINES
OSHA REGULATION 29CFR1910.1000 REQUIRES THE FOLLOWING PERMISSIBLE
EXPOSURE LIMITS:
A TWA of 100 ppm (525 mg/m3) for Stoddard Solvent.
A TWA of 25 ppm (125 mg/m3) for Trimethyl Benzene.
The recommended permissible exposure levels indicated above reflect the
levels revised by OSHA in 1989 or in subsequent regulatory activity.
Although the 1989 levels have since been vacated by the 11th Circuit Court
of Appeals, Exxon Chemical recommends that the lower exposure levels be
observed as reasonable worker protection.
THE ACGIH RECOMMENDS THE FOLLOWING THRESHOLD LIMIT VALUES:
A TWA of 100 ppm (525 mg/m3) for Stoddard Solvent.
A TWA of 25 ppm (123 mg/m3) for Trimethyl Benzene.
EXXON RECOMMENDS THE FOLLOWING OCCUPATIONAL EXPOSURE LIMITS:
100 ppm total hydrocarbon based on composition.
SECTION 9 PHYSICAL AND CHEMICAL PROPERTIES
SPECIFIC GRAVITY at Deg F:
VAPOR PRESSURE, mmHg at Deg F:
SOLUBILITY IN WATER, wt. 96 at Deg F:
VISCOSITY OF LIQUID, cSt at Deg F:
SP. GRAV. OF VAPOR, at 1 atm (Air=1):
FREEZING/MELTING POINT, Deg F:
EVAPORATION RATE, n-Bu Acetate=1:
BOILING POINT, Deg F:
0.80 at 60
2 at 68 Approximate
Less than 0.01 at 77 4 ..-
1.3 at 77 Approximate
3.50 Calculated
1
Less than 0.1
315 to 394
SECTION 10 STABILITY AND REACTIVITY
STABILITY:
Stable
CONDITIONS TO AVOID INSTABILITY:
Peroxide hazard on concentration;
inhibitor has been added to mitigate
peroxide hazard
HAZARDOUS POLYMERIZATION:
Will not occur
CONDITIONS TO AVOID HAZARDOUS POLYMERIZATION:
Not Applicable
MATERIALS AND CONDITIONS TO AVOID INCOMPATIBILITY:
Halogens, molten sulfur, strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS:
None
Continues on page
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MATERIAL SAFETY DATA SHEET
EXXON CHEMICAL COMPANY
A Division of EXXON CORPORATION
PAGE: 6
DATE PREPARED: MAY 31, 1997
MSDS NO.: 92890627
VARSOL 1 SOLVENT
SECTION 11 TOXICOLOGICAL INFORMATION
Please refer to Section 3 for available information on potential health
effects.
SECTION 12 ECOLOGICAL INFORMATION
No specific ecological data are available for this product. Please refer to
Section 6 for information regarding accidental releases and Section 15 for
regulatory reporting information.
SECTION 13 DISPOSAL CONSIDERATIONS
Please refer to Sections 5, 6 and 15 for disposal and regulatory information.
SECTION 14 TRANSPORT INFORMATION
DEPARTMENT OF TRANSPORTATION (DOT):
DOT SHIPPING DESCRIPTION: PETROLEUM DISTILLATE, N.O.S., COMBUSTIBLE LIQUID,
UN 1288, III
Note: In containers of 119 gallons capacity or less this product
is not regulated by DOT.
SECTION 15 REGULATORY INFORMATION
TSCA:
This product is listed on the TSCA Inventory as a UVCB (Unknown, Variable
Composition or Biological) Chemical at CAS Registry Number 8052-41-3
Clean Water Act/Oil Pollution Act:
This product is classified as an oil under Section 311 of the Clean
Water Act (40 CFR 110) and the Oil Pollution Act of 1990. Discharge
or spills which produce a visible sheen on either surface water, or
in waterways/sewers which lead to surface water, must be reported to
the National Response Center at 800-424-8802.
CERCLA:
If this product is accidentally spilled, it is not subject to any special
reporting under the requirements of the Comprehensive Environmental Response,
Compensation and Liability Act. We recommend you contact local authorities
to determine if there may be other local reporting requirements.
SARA TITLE III:
Under the provisions of Title III, Sections 311/312 of the Superfund
Amendments and Reauthorization Act, this product is classified into the
following hazard categories:
Delayed Health, Fire.
Continues on page 7

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1 Aug 1997 16:46
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Page 8 of 22
VARSOL 1 SOLVENT
MATERIAL SAFETY DATA SHEET
EXXON CHEMICAL COMPANY
A Division of EXXON CORPORATION
PAGE: 7
DATE PREPARED: MAY 31, 1997
MSDS NO.: 92890627
This information may be subject to the provisions of the Community
Right -to -Know Reporting Requirements (40 CFR 370) if threshold quantity
criteria are met.
This product contains the following Section 313 Reportable Ingredients:
COMPONENT CAS # MAX. 96
1,2,4 Trimethylbenzene 95-63-6 4.0
SECTION 16 OTHER INFORMATION
HAZARD RATING SYSTEMS:
This information is for people trained in:
National Paint & Coatings Association's (NPCA)
Hazardous Materials Identification System (HMIS)
National Fire Protection Association (NFPA 704)
Identification of the Fire Hazards of Materials
NPCA-HMIs NFPA 704
HEALTH 1 0
FLAMMABILITY 2 2
REACTIVITY 0 0
REVISION SUMMARY:
Since May 23, 1996 this MSDS has been revised in Section(s):
10
KEY
4 = Severe
3 = Serious
2 = Moderate
1 = Slight
0 = Minimal
REFERENCE NUMBER: SUPERSEDES ISSUE DATE:
HDHA-C-25038 May 23, 1996
This information relates to the specific material designated and may not be
valid for such material used in combination with any other materials or in any
process. Such information is to the best of our knowledge and belief,
accurate and reliable as of the date compiled. However, no representation,
warranty or guarantee is made as to its accuracy, reliability or completeness.
It is the users responsibility to satisfy himself as to the suitability and
completeness of such information for his own particular use. We do not accept
liability for any loss or damage that may occur from the use of this
information nor do we offer warranty against patent infringement.
f
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02/27/98 FRI 15:33 FAX
VAPOR PRESSURE (mmHg)
1000
100
10
1
0.1
VARSOL 1
_...._.__........__..1....._..___._...
..._._.......--
r
0
50 100 150 200
TEMPERATURE ("F)
Temperature fin
VPVARSOLXLS
222025
Z0'd LtiL2 SEti AIL
40
50
60
68
77
100
150
200
250
300
Co 009
260 300 350
Vapor PressurejmmHq)
0.69
1.04
1.53
2.09
2.92
6.46
28.01
92.17
247.18
567.12
ikip320
11 - NOXXG 0E : V T L66T-90-9fld

15:33 FAX
THE
MERCK INDEX
AN ENCYCLOPEDIA OF
CHEMICALS, DRUGS, AND BIOLOGICALS
ELEVENTH EDITION
Susan Budavari, Editor
Maryadele J. O'Neil, Associate Editor
Ann Smith, Assistant Editor
Patricia E. Heckelman, Editorial Assistant
Published by
MERCK & CO., INC.
RAHWAY, N.J., U.S.A
1989

02/27/98 FRI 15;33 FAX
6119 Minaprine
isoln: N. K. Hart et aL, Heterocycles 7, 265 (1977). Struc-
ture: Adams, Jones, J. Am. Chem. Soc. 69, 1803 (1947).
Synthesis: Adams, Johnson, ibid. 71, 705 (1949). Identity of
mimosine and leucenol: Klcipool, Wibaut, Rec. Tray. Chico.
69, 37 (1950); Wibaut, Schuhmacher, ibid. 71, 1017 (1952).
Crystal structure: A. Mostad et al.. Acta Chem. Scand. 27,
164 (1973). Shown to cause inhibition of hair growth and
loss of hair in mice: Crounse et at, Nature 194, 694 (1962).
Explanation of the toxicity in animals: J. F. Thompson et
aL, Ann. Rev. Binchem. 38, 137 (1969).
d!-Form, crystals from water, cop 235-236°. Slightly sol
in water, touch less sol in methanol and ethanol; practically
insol in the higher alcohols, in dioxane, ethyl acetate, ether,
benzene, chloroform, glacial acetic acid, pyridine, Cellosolve.
Sol in dil acids or bases and may be recovered from these
solns by adjusting the pH so that it is just acid to broincre-
sol green. ttv max: 282 nm (log E 4.23).
d1-Hemihydrate, crystals, darkens at. 215-226°, mp 227-
228°.
1-Form, crystals from water, mp 225'. [a]f —20°.
Hydrochloride, C,,H13CINt04, dee 175°, sol in water.
Hydrobromide. CH11BrN20„ des 179.5', sol in water.
Usti: Depilatory agent, Hegarty et aL, Aust. J. Agr. Res. 15,
153 (1964), C.A. 60, 16405e (1964),
6119. 1Vlinaprine. N-(4-Methyl-6-phenyl-3-pyridazin-
yl)-4-,norpholincethanamine; 4-j2-04-methy!•6-phenyl-3.
pyridazinyl)anrinoJetlrydjnurpltoline. C1}HaN4O; cool wt
298.40. C 68.43%, it 7.43%, N 18.78%, 0 5.36%. Prepn: H.
Laborit, Ger. pat. 2,229,215; ident, U.S. pat. 4,169,158
(1973. 1979 to Centre Etudes Expel-. Clin. Physio-Biologic);
C.-G. Wcrmuth. A. Exingcr, Agressnlogie 13, 285 (1972).
Pharmacology: 1'1. Laborit et at., ibid. 291. Metabolism of
14C-minaprinc: A. G. Rico et al., J. Pharmacol. 9, 170
(1978). Pharmacokinetics: J. P. Jeanniot et al., ibid. 169.
Clinical evaluation: A. Garcia-Mafila, M. H. do Garcia,
Pharntatherapeuticu 2, 265 (1979). Pharmacological evalua-
tion in depression: K. Biziere et aL, Arzneimittel-Forsch. 32,
824 (1982). Toxicologic study: A. G. Mazure er al.. Agres-
sologie 13, 319 (1972).
hITCHZC112 \ /
Ca,
Fine huff -colored needles from isopropanol, cop 122".
lnsol in water. Slightly sol in cold ethanol, sol in hot etha-
nol, chloroform.
Dihydrochloride. C17H29C15N40, Agr 1240, C11-30038,
Srattur, Cantor. Crystals from abs ethanol, mp 182".
THERM, CAT: Psychotropic.
6120. Mineral Splrit.S. Petroleum spirits; white spirits;
turpentine substitutes. Name applied to various types of
hydrocarbon solvents, primarily petroleum distillates, which
have flash points above 100'F (38°C) and distillation ranges
between 300°F (149°C) and 415°F (213'C). See: A.S.T.M.
Standard Specifications D 235-83, 71-73 (1983).
Type 1, Stoddard solvent, Texxolre S, Varsol 1. Regular
mineral spirits. Clear liquid. Flash pt (min): 38°C (100°F).
d15,M1 0.754.0.820. Distillation range: initial bp (min), 149"C
(300°F); 50% recovered (max), 182°C (360°F); dry pt (max),
208°C (407°F'),
Type 11. High flash point mineral spirits. flash pt (min):
60°C (140"F). dj56 0.768-0.820. Distillatiun range: initial
bp (min), 177°C (350"F); 50% recovered (max), 196°C
(385"F); dry pt (max). 211"C (412°F).
Type II1. Odorless mineral spirits. Flash pt (min): 3 C (too°F). d]s- 0.775 (max). Distillation range' initial b
dry pt (max),(2103 C)(415°F).ecovered (max), 196°C (385°Fj
Type IV, Texeolt'e S-2, Varsnl 3. I..ow dry point ntinrrnl
spirits. Flash pt (mitt): 38°C (100°F). dal 0.754-0 g%
Distillation range: initial bp (min), 149°C (300°F): 50-.
recovered (max), 174`C (3457); dry pt (max), 18� C (36r1')
clean: Solvent;epaint thinner. In the coatings and dry
6121. Minocycline. 4,7-I3is(dinrethylamino)-p a 4a,5„
5a, 6, I I, f 2a-octa h yd ro-3, 10, I2, 12a-t et ra hydroxy-1,1 l •di naa
2-napltthacenecarboxamide; 7-dimcthylamino-6-dentethlq.
6-deoxytetracycline; Minocyn. C13H27N307; mot wt 457.49
C 60.38%, Ii 5.95%, N 9.18%, 0 24.48`,''c, Semi-syntltetk
antibiotic effective against tetracycline -resistant staphylo,
cocci. Prepn: Boothe, Petisi, U.S. pats. 3,148,212 into
3,226,436 (1964 and 1965 to Am. Cyanamid). Synthesis
Martell, Boothe, J. Med. Chem. 1(1, 44 (1967); Church era!,
J. Org, Chern. 36, 723 (1971); Bernardi et al., Farmuco &I,
Set 30, 736 (1975). Activity data: Kradolfer et al., Antlnti,
crab. Ag. Chemother. 1966, 359. Metabolism: Kelly, Kane,
gis, Toxicol. Appt Pharrrtacal, 11, 171 (1967). Toxicity slug,
ics: Noble et al., ibid. 128. Clinical evaluation: Frisk,
Tunevall, Anrienicrob. Ag. Chemother. 1968, 335; Cappel,
Klastersky, Curr. Thee. Res. 13, 227 (1971). Comprehends[
description! V. Zbinovsky, G. P. Chrekian in Analytical
Profiles of Drug Substances vol. 6, K. Florey, Ed. (Academic
Press, New York, 1977) pp 323-339.
(C113)5N H H 8(CH3)2
. off
COM
1 1 OH E.
OH 0 0H O
Bright yellow -orange amorphous solid. In]p —166° (c
0.524). uv max (0.1N HC1): 352, 263 rim (log a 4.16, 4,21).
(0.1 N Na0H): 380, 243 nm (log e 4.30, 4.38).
Hydrochloride, C23H3NCIN307, Minncin, Klinetnycl6,
bfirrotrtycin, Vectrin. Yellow crystalline powder. Slightly
hygroscopic; sensitive to light and to surface oxidation.
THERAI' CAT: Antibacterial.
6122. Minoxidll• 64I-Piperidinyl)-2,4-pyrintidinedb
amine 3-oxide; 6-amino•1,2•diltydro-l-hydroxy2-iritina4
piperidirtopyrirnidine; 2,3-diltydra-3-hydroxy-2-imin0.6•
(1-piperidinyl)-4-pyrimidinaminc; 2,4-diamino-6-piperidl•
nopy'rintidine 3-oxide; 6-piperidino-2,4-diatninopyritnidtnt
3-oxide; P12P; U-i0,858; Alopexil; Alostil; Lanitert; 1,01O'
lox; Minoximcn; Prexidil; Rogaine; Rogaine; Tricoxidil. ty
H15N50; mot wt 209.25. C 51.66%, H 7.225, N 33.47%, A
7.65% Prepn: Neth. pat. Appl. 6,615,385; W. C. Anthony
et al., U.S. pat. 3,382,247 (1967, 1968 both to Upjohn); 1.
M. McCall et al., J. Org. Cheat. 40, 3304 (1975), See also
C. Anthony, U.S. pat. 3,644,364 (1972 to Upjohn). Melsb•
olism: R. C. Thomas et al., J. Pharnt, Sci. 64, 1360 (1974
Pharmacology and pharmac.okinetics: D. T. Lowenthal e1
al., J. Clin. Pharmacol. 18, 500 (1978). Percutaneous ab•
sorption and excretion: '1'. J. Franz, Arch. Dennatol, 121,
203 (1985). Clinical studies; O. Andersson, R. SivcrtuslM•
Acta Med. Scand. 205, 213 (1979); M. Moser, Adran• fir°
dial. 26, 38 (1979). Clinical trial in early male pattern mod'
ness: E. A. Olsen et al., J. Am. Acad. Derm°tol. 13, lltj
(1985). Toxicology; R. G. Carlson, E. 5. Feenstra, ToF4
Appl. Pharmacol- 39, 1 (1977). Review of phartomacolog g81
therapeutic use: V. M. Caese, Drugs 22, 257-278 (I
Review of topical application in baldness: E. Novak et °1"
Int, J. Dennatol. 24, 82 (1985). Comprehensive descoPilO t
D. K. J. Gorecki in Analytical Profiles of Drug Subs lgB6?
vol. 17, K. Florey, Ed. (Academic Press. New Y°rk,
185-219.
Page 976 Cart.sUlf the cross index before using this section.
011
Crystals from melt an
161° (Anthony, 1972)- 1
261, 285 nm (E 35210, 1
{836 00E 211t400, 2120 0)
le, methanol 44, etltano
oxide 6.5, water 2.2, ch
acetate <0.5, diethyl etl-
c0.5. LD,a in rats, m
recnstra)-
THERAP CAT: Antibyp'
6123. Miokamycin.
diPrupanuare; 9,3"-disc
ntycin; Mi°camycin.
t,p.18%, H 7.97%, Nr,.5
dcriv of midecamy t
8ok5i 74 124087 (1974
0moto el al., J. Antibiot
Chem. Letters 1978, 171
tics of crystalline and
rl al., Chem. Pharnt, B.
vivo antibacterial activil
34, 436 (1981). Meta
Mann. Bull. 29, 2413
studies: U. Shibata et
C.A. 96, 62631x (1982
studies: Y. Toyonaga
216y (1983). Mutagcni
Antibiot. 34, 443 (1981
P - oct5,CII.,
II
Tasteless crystals I
coloration). [n]„ — 5.
(c = 1 in methanol):
acetone, chloroform.
crystalline form cony,
squcous suspension.
kiln, the non -crystal)
than the crystalline f,
ntERAP CAT: Antit!
6124, Mipafox,
4m
ridr;idic bis6sopropylfluoride;anN,
Pestox Xv. C HiF
A.ttS %, F 10.43%, tN
P°and ct al., Brt. p
Cheri. Soc. 1956, 37
Crystals, cop 65°.
t'sE: Insecticide.
6125, Miraculin,