NCGNE0640_COMPLETE FILE - HISTORICAL_20110908

STORMWATER DIVISION CODING SHEET
NCG PERMITS
PERMIT NO.
NCGNE OhyC�
DOC TYPE
VHISTORICAL FILE
DOC DATE
❑ (5Ul I D 1 D&I
YYYYMMDD

NC®ENR
North Carolina Department of Environment and Natural Resources
Division of Water Quality
Beverly Eaves Perdue Colleen H. Sullins Dee Freeman
Governor Director Secretary
September 8, 2011
Karen Ananea
Inspire Pharmaceuticals Inc - Inspire Pharmaceuticals, Inc.
4222 Emperor Blvd
Durham, NC 27703
Subject: Rescission ofNPDES Stormwater Permit
Certificate of Coverage Number NCGNE0640
Inspire Pharmaceuticals Inc - Inspire Pharmaceuticals,
Inc.
Durham County
Dear Permittee:
On 3/18/201 I, the Division of Water Quality received your request to rescind your coverage under
Certificate of Coverage Number NCGNE0640. In accordance with your request, Certificate of Coverage
Number NCGNE0640 is rescinded effective immediately.
Operating a treatment facility, discharging wastewater or discharging specific types of stormwater to
waters of the State without valid coverage under an NPDES permit will subject the responsible party to a
civil penalty of up to $25,000 per day. It is the intention of DWQ that enforcement proceedings will
occur for persons that have voluntarily relinquished permit coverage when, in fact, continuing permit
coverage was necessary. If, in retrospect, you feel the site still requires permit coverage, you should
notify this office immediately. Furthermore, if in the future you wish to again discharge to the State's
surface waters, you must first apply for and receive a new NPDES permit.
If the facility is in the process of being sold, you will be performing a public service if you would inform
the new or prospective owners of their potential need for NPDES permit coverage.
If you have questions about this matter, please contact Brian Lowther at [phone], or the Water
Quality staff in our Raleigh Regional Office at NPDES SW.
Sincerely,
/U `��o'
for Coleen H.
Sullins, Director
cc: Raleigh Regional Office
Stormwater Permitting Unit
Fran McPherson, DWQ Budget Office - please waive applicable fees
Wetlands and Stormwaler Branch
161 i Mail Service Center, Raleigh, North Carolina 2i 699-1617
Location'. 512 N. Salisbury St. Rdleigh, North Carolina 2760 f
Phone: 91M 7-63001 FAX: [phone]• 1 Customer Service. 1-87'-623-6748
Inte- :et www ncwatemualily or-
An %al Oppormity 1 Affrmallve Achon Emplo;•er
One .
NorthCarolina
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Adj A
NCDENR
North Carolina Department of Environment and
Division of Water Quality
Beverly Eaves Perdue Coleen H. Sullins
Governor Director
October 10, 2009
Ms. Karen Ananea
Inspire Pharmaceuticals, Inc.
4222 Emperor Blvd., Suite 200
Durham, NC 27703
G�71t�L�ii7
Natural Resources
Subject: Application for No -Exposure Certification
Permit No. NCGNE0640
Inspire Pharmaceuticals, Inc.
Durham
Durham County
Dear Ms. Ananea:
Dee Freeman
Secretary
The Division has reviewed your submittal of the No -Exposure Certification for Exclusion from NPDES Stormwater
Permitting form and made a site visit to assess the potential for stormwater pollution. Based on our observations and
your submittal and signed certification of no exposure at the above referenced facility, the Division is granting your
conditional exclusion from permitting as provided for under 40 CFR 126.22(g), which is incorporated by reference in
North Carolina regulations.
Please note that by our acceptance of your no -exposure certification, you are obligated to maintain no -exposure
conditions at your facility. If conditions change such that your facility can no longer qualify for a no -exposure
exclusion, you are obligated to immediately obtain NPDES permit coverage for your stormwater discharge.
Otherwise, the discharge becomes subject to enforcement as an un-permitted discharge (subject to civil penalties
of up to $25,000 per day). Your conditional no -exposure exclusion expires in five years (October 9, 2014). At that
time you must re -certify with the Division, or obtain NPDES permit coverage for any stormwater discharges from
your facility.
Your conditional exclusion from permitting does not affect your facility's legal requirements to obtain environmental
permits that may be required under other federal, state, or local regulations or ordinances.
If you have any questions or need further information, please contact Myrl Nisely at (919) 7�-1-4200 or at
[e-mail]. /
Sinc rely,
L
/I
for Coleen H. ullins
cc::RRO / SWP Files
Stormwater Permitting Unit No -Exposure Files
Ni rthCarolina
JVatura!!y
North Carolina Division of water Quality 1628 Mail Service Center Raleigh, NC 27699-1628 Phone [phone] Customer Service
Internet: w .ncwaterguality org Location: 3800 Barrett Drive Raleigh, NC 27609 Fax [phone]
An Equal Opportunity/Affirmative Action Employer— 50% Recycled/10% Post Consumer Paper

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+4—..+...�....e..1111111111—Vision of Water Quality
El Division of Soil and Water Conservation
❑ Other Agency
Facility Number: Facility Status: Active Permit: NCGNE0640 ❑ Denied Access
Inspection Type: Stormwater Inactive or Closed Date:
Reason for Visit: Routine County: Durham Region: Raleigh
Date of Visit: 10/07/2009 Entry Time:02:00 PM Exit Time: 02A5 PM Incident #:
Farm Name: Inspire Pharmaceuticals Inc Owner Email:
Owner: Inspire Pharmaceuticals Inc
Mailing Address: 4222 Emperor Blvd Ste 200 Durham NC 27703
Physical Address: 4222 Emperor Blvd Ste 470 Apex NC 27502
Phone: [phone]
Facility Status:. Compliant ❑ Not Compliant Integrator:
Location of Farm: Latitude: Longitude:
Question Areas:
Certified Operator: Operator Certification Number:
Secondary OIC(s):
On -Site Representative(s): Name Title Phone
24 hour contact name Karen Ananea Phone: [phone]
Primary Inspector: Myrl Nisely `.,t Phone:
Inspector Signature: _. N/� \ - a.a Date: 10
Secondary Inspector(s): 17
Inspection Summary:
This facility is merely a modern office building. The exterior has no potential pollutants of any kind and shows meticulous
housekeeping and landscaping. Activities are administrative, including the paperwork for manufacturing that is done in other cities
and clinical pharmaceutical trials carried out at medical facilities.
NE is granted.
Page:1

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Division of Water Quality ) Surface Water Protection
National Pollutant Discharge Elimination System
NO EXPOSURE CERTIFICATION for Exclusion
NCGNE0000
NO EXPOSURE CERTIFICATION
FOR AGENCY USE: ONLY
Uwe Receive)
Year
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NICIGIN E
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Please check here if this is a renewal: ❑ RENEWAL
National Pollutant Discharge Elimination System application for exclusion from a Stormwater Permit based
on NO EXPOSURE:
Submission of this No Exposure Certification constitutes notification that your facility does not
permit for stormwater discharges associated with industrial activity in the State of North Carolil
it qualifies for a no exposure exclusion. A condition of no exposure at an industrial facility mea
industrial materials and activities are protected by a storm resistant shelter (with some exceptic
prevent exposure to rain, snow, snowmelt, and/or runoff.
For permitted facilities in North Carolina, DWQ must approve your application f
Exposure Certification before this exclusion is effective. Until you are issued a
Exposure Certification and your NPDES permit is rescinded, your facility must 1
to abide by the terms and conditions of the current permit.
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Industrial materials or activities include, but are not limited to: material handling equipment or activities,
industrial machinery, raw materials, intermediate products, by-products, final products, or waste products.
Material handling activities include the storage, loading and unloading, transportation, or conveyance of
any raw material, intermediate product, final product or waste product. A storm resistant shelter is not
required for the following industrial materials and activities: drums, barrels, tanks, and similar containers
that are tightly sealed, provided those containers are not deteriorated and do not leak. "Sealed" means
banded or otherwise secured and with locked or non -operational taps or valves; adequately maintained
vehicles used in material handling; and final products, other than products that would be mobilized in
stormwater discharges (e.g., rock salt).
A No Exposure Certification must be provided for each facility qualifying for the no exposure exclusion. In
addition, the exclusion from NPDES permitting is available on a facility -wide basis only —not for individual
outfalls. If any industrial activities or materials are, or will be, exposed to precipitation, the facility is not
eligible for the no exposure exclusion. By signing and submitting this No Exposure Certification form, you
certify that a condition of no exposure exists at this facility or site and are obligated to comply with the
terms and conditions of 40 CFR 122.26(g).
You are required to reapply for the No Exposure Exclusion once every five (5) years.
For questions, please contact the DWO Regional Office for your area. (See page 6)
(Please print or type)
1) Mailing address of owner/operator (address to which all certification correspondence will be mailed):
Name
Contact
Street Address
City
Telephone No.
Page t of 7
61-,11-3-4 e, /
SWU-NE-021309 Last revised 2/13/2009

NCGNE0000 No Exposure Certification
2) Location of facility producing discharge
Facility Name Z h 5� /P hQ imp e U / I CG A. Zhc
Facility Contact Ala,-eii 1744e c,
Street Address Ll-,;� 2 2 9S121 ?r'Dr- VW, , Szj'l 490
City L _�!'/'?�!�'� .State IVC ZIP Codea'25-0
County a m
Telephone No. gig `1/-qrJ Fax: 9✓1/SAD/
3) Physical location information:
Please provide a narrative description of how to get to the facility (use street names, state road numbers, and
distance and direction from a roadway intersection). HwV Y0— e i2gi
/✓cl
(A copy of a map with the facility clearly located on it should be included with the certification application.)
4) Is the facility located on Native American Lands? ❑ Yes 0-M-0
5) Is this a Federal facility? ❑ Yes CAO
6) Latitude z Longitude ? (deg., min., seconds)
7) This NPDES No Exposure Exclusion application applies to which of the following:
El New or Proposed Facility Date operation is to begin
6"/Existing Date operation began /o .Z g - 9 3
❑ Renewal of existing No Exposure Certification Certification No.: NCGNE /
8) Was this facility or site ever covered under an NPDES Stormwater Permit? ❑ Yes [9'No
If yes, what is the NPDES Permit Number?
9) Standard Industrial Classification:
Provide the 4 digit Standard Industrial Classification Code (SIC Code) that describes the primary industrial
activity at this facility
4/
IACode: a S
10) Provide a brief description of the types of industrial activities and products produced at this facility:
�c✓rrilnl'sf--a �F Z�s W/s6sne /a/�a a�Gfr/ uv�lL
11) Does this facility have any Non -Discharge permits (ex: recycle permits)?
18'(Vo
❑ Yes
If yes, list the permit numbers for all current Non -Discharge permits for this facility:
Page 2 of 7
SWU-NE-021309 Last revised 2/13I2009

NCGNE0000 No Exposure Certification
Exposure Checklists (12. - 14.)
12) Are any of the following materials or activities exposed to precipitation, now or in the foreseeable
future? (Please check either "Yes" or "No.") If you answer "Yes" to any of these items, you are not
eligible for the no exposure exclusion.
a. Using, storing, or cleaning industrial machinery or equipment, and areas where a Yes FAo ❑ N/A
residuals from using, storing or cleaning industrial machinery or equipment remain
and are exposed to stormwater
b. Materials or residuals on the ground or in stormwater inlets from spills/leaks ❑ Yes RrNo ❑ N/A
c. Materials or products from past industrial activity
❑ Yes
"o
❑ N/A
d. Material handling equipment (except adequately maintained vehicles)
❑ Yes
2 No
❑ N/A
e. Materials or products during loading/unloading or transporting activities
❑ Yes
"o
❑ N/A
f. Materials or products stored outdoors (except final products intended for outside
❑ Yes
allo
❑ N/A
use [e.g., new cars] where exposure to stormwater does not result in the discharge
of pollutants)
g. Materials contained in open, deteriorated or leaking storage drums, barrels, tanks,
❑ Yes
¢'NO
❑ N/A
and similar containers
h. Materials or products handled/stored on roads or railways owned or maintained by
❑ Yes
2-Ko
❑ N/A
the discharger
i. Waste material (except waste in covered, non -leaking containers [e.g., dumpsters])
❑ Yes
2NO
❑ N/A
j. Application or disposal of process wastewater (unless otherwise permitted)
❑ Yes
I;Ao
❑ N/A
k. Particulate matter or visible deposits of residuals from roof stacks and/or vents not ❑ Yes 26o ❑ N/A
otherwise regulated (i.e., under an air quality control permit) and evident in the
stormwater outflow
I. Empty containers that previously contained materials that are not properly stored ❑ Yes f;fo ❑ N/A
(i.e., not closed and stored upside down to prevent precipitation accumulation)
m. For any exterior ASTs, as well as drums, barrels, tanks, and similar containers ❑ Yes 5 o ❑ N/A
stored outside, has the facility had any releases in the past three (3) years?
13) Above Ground Storage Tanks (ASTs): It you answer "No" to any of the following items, you are not
eligible for the no exposure exclusion.
a. Are exterior ASTs or piping free of rust, damaged or weathered coating, pits, or
deterioration, or evidence of leaks?
b. Is secondary containment provided for all exterior ASTs? It so, is it free of any
cracks, holes, or evidence of leaks, and are drain valves maintained locked shut?
❑ Yes ❑ No 2</A
❑ Yes ❑ No a<A
Page 3 of 7
SWU-NE-021309 Last revised 2/13/2009

NCGNE0000 No Exposure Certification
14) Secondary Containment: If you answer "No" to any of the following items, you are not eligible for the
no exposure exclusion.
a. Is secondary containment provided for single above ground storage containers
(including drums, barrels, etc.) with a capacity of more than 660-gallons?
b. Is secondary containment provided for above ground storage containers stored
in close proximity to each other with a combined capacity of more than 1,320-
gallons?
c. Is secondary containment provided for Title III Section 313 Superfund
Amendments and Reauthorization Act (SARA) water priority chemicals`?
d. Is secondary containment provided for hazardous substances" designated in 40
CFR §116?
e. Are release valves on all secondary containment structures locked?
15) Hazardous Waste:
a. Is this facility a Hazardous Waste Treatment, Storage, or Disposal Facility?
b. Is this facility a Small Quantity Generator (less than 1000 kg. of hazardous waste
generated per month) of hazardous waste?
c. Is this facility a Large Quantity Generator (1000 kg. or more of hazardous waste
generated per month) of hazardous waste?
If you answered yes to questions b. or c., please provide the following information:
Type(s) of waste: 01�9
How is material stored:
Where is material stored:
How many disposal shipn
Name of transport / dispo
Vendor address: V'74
Footnotes to Questions 14) c. & d.
❑ Yes ❑ No B-N/A
❑ Yes ❑ No ❑-N/A
❑ Yes ❑ No O N/A
❑ Yes ❑ No R(N/A
❑ Yes O No C"N/A
❑ Yes [7 No ❑ N/A
ales ❑ No ❑ N/A
❑ Yes l I- ❑ N/A
'Note that amounts below the 660-gallon (single) and 1,320-gallon (combined) bulk storage minimums require
secondary containment. However, some exceptions may be made for de minimis amounts of certain substances,
and/or other qualifiers, as described in the exemptions from reporting requirements of Title III SARA 313 in 40 CFR
§372.38.
"Note that amounts below the 660-gallon (single) and 1,320-gallon (combined) bulk storage minimums require
secondary containment. However, some exceptions may be made for amounts less than the Reportable Quantities
of the hazardous substances listed in 40 CFR §117.3.
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NCGNE0000 No Exposure Certification
16) Other information: If you answer "Yes" to any of the following items, you might not be eligible for the
no exposure exclusion. A more in-depth evaluation of the site circumstances may be required.
a. Does your facility store used, recycled, or otherwise reclaimed pallets outside? ❑ Yes 2110 ❑ N/A
b. Does your facility have coal piles on site?
C. Does your facility store other fuel sources outside in piles, such as wood chips,
sawdust, etc.?
d. Does your facility have air emissions associated with its industrial activity (e.g.,
degreasing operations, plating, painting and metal finishing)? If so, describe the
industrial activity:
e. If you answered yes to d., are those emissions permitted by an Air Quality Permit?
Please specify:
I. Please list any other environmental program permits (federal, state, etc.) not
specified earlier in this application (such as Hazardous Waste Permits, etc.):
Permit:
Program:
Permit:
Program:
Permit:
Program:
Permit:
Program:
Permit:
Program:
Permit:
Program:
Permit:
Program:
❑ Yes q.l4o ❑ N/A
❑ Yes ID No ❑ N/A
❑ Yes [;,No ❑ N/A
❑ Yes ❑ No ❑ N/A
Page 5 of 7
SWU-NE-021309 Last revised 2/13/2009

NCGNE0000 No Exposure Certification
17) Certification:
I certify under penalty of law that I have read and understand the eligibility requirements for claiming a condition of "no
exposure" and obtaining an exclusion from NPDES stormwater permitting.
I certify under penalty of law that there are no discharges of stormwater contaminated by exposure to industrial activities
or materials from the industrial facility or site identified in this document (except as allowed under 40 CFR 122.26(g)(2)).
I understand that I am obligated to submit a no exposure certification form once every five (5) years to the North Carolina
Division of Water Quality and, if requested, to the operator of the local municipal separate storm sewer system (MS4) into
which the facility discharges (where applicable). I understand that I must allow the North Carolina Division of Water
Quality, or MS4 operator where the discharge is into the local MS4, to perform inspections to confirm the condition of no
exposure and to make such inspection reports publicly available upon request.
In the event that the site no longer qualifies for a No Exposure Exclusion, I understand that I must obtain coverage under
an NPDES permit prior to any point source discharge of stormwater from the facility. Additionally, I certify under penalty of
law that this document and all attachments were prepared under my direction or supervision in accordance with a system
designed to assure that qualified personnel properly gathered and evaluated the information submitted. Based on my
inquiry of the person or persons who manage the system, or those persons directly responsible for gathering the
information, the information submitted is to the best of my knowledge and belief true, accurate and complete. I am aware
that there are significant penalties for submitting false information, including the possibility of fine and imprisonment for
knowing violations.
I certify that I am familiar with the information contained in this application and that to the best of my knowledge and belief
such information is true, complete, and accurate. nn
Printed Name of Person Signinn/gT: .Kq, /Cr1 an a,, eA
Title: Fa Gi���"1 GS II tQ Vlagrr
C i1AAA 015101
y
(Signature of Applicant) (Date Siged)
Please note: This application for the No Exposure Exclusion is subject to approval by the
NCDENR Regional Office prior to issuance. The Regional Office may inspect your facility for
compliance with no exposure conditions prior to that approval. The Regional Office may also
inspect your facility at any time in the future for compliance with the No Exposure Exclusion.
North Carolina General Statute 143-215.6 B(i) provides that:
Any person who knowingly makes any false statement, representation, or certification in any application, record, report, plan, or other
document filed or required to be maintained under this Article or a rule implementing this Article; or who knowingly makes a false
statement of a material fact in a rulemaking proceeding or contested case under this Article; or who falsifies, tampers with, or knowingly
renders inaccurate any recording or monitoring device or method required to be operated or maintained under this Article or rules of the
[Environmental Management] Commission implementing this Article shall be guilty of a Class 2 misdemeanor which may include a fine
not to exceed ten thousand dollars ($10,000).
There is currently no fee for a No Exposure Exclusion.
Page 6 of 7
SWU-NE-021309 Last revised 2113/2009

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4222 Emppor Blvd, Durham, NC - Google Maps
Page I of I
Address 4222 Emperor Blvd
Google maps Durham, NC 27703
Get Google Maps on your phone
Text the word"GIVIAPS" to 466453
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9/17/2009