DEQ-CFW_00049771

From: Detlef Knappe [[e-mail]]
Sent: 7/5/2017 2:25:26 PM
To: Risen, Amy J [/o=ExchangeLabs/ou=Exchange Administrative Group
(FYDI BO H F23SPDLT)/cn=Recip ients/cn =f 72096b57ee847cOa 13f73d2O6edf e86-aj risen]; Holman, Sheila
[/o=ExchangeLabs/ou=Exchange Administrative Group
(FYDI BOHF23SPDLT)/cn=Recipients/cn=94a3f69674d34b769b3bd834a97105c5-schoI man]; Grzyb, Julie
[/o=ExchangeLabs/ou=Exchange Administrative Group
(FYDIBOHF23SPDLT)/cn=Recipients/cn=75dl654d45154c2abbO8596a2c9af282-jagrzyb]; Godreau, Jessica
[/o=ExchangeLabs/ou=Exchange Administrative Group
(FYDIBOHF23SPDLT)/cn=Recipients/cn=754d9266f43445529ef3892420aa44el-jcgodreau]
Subject: Fwd: Re: Dutch GenX tox review
Please read from the bottom up.
I am also copying Sheila, Julie, and Jessica. Should anyone else take a look at this information?
Thank you,
Detlef
- Forwarded Message --------
Subject:Re: Dutch GenX tox review
Date:Wed, 05 Jul 2017 10:14:49 -0400
Fro :PC <p.cohnLo)comcast.net>
To:Detlef Knappe <knappe L-�,ticsu.edu>
Of course you can share it with folks at NCDHHS.
In addition, I am available formally or informally as a reviewer with background and
experience in toxicology, epidemiology, risk assessment and public health policy. (My
work included epidemiologic research on chemicals, radioactivity and microorganisms.)
I've also worked as a technical advisor on a several AWWARF/USEPA projects and was a lead
author and coauthor on health effects chapters in two editions of AWWA's Water Quality
and Treatment.
On July 5, 2017 7:52:05 AM EDT, Detlef Knappe <[e-mail]> wrote:
>Thank you for sending this information, Perry. Do you mind if I share
>your email with staff in the NC DHHS?
>Detlef
>On 7/3/17 11:51 AM, Perry Cohn wrote:
>> Dutch GenX tox review
>> I would like to share this link to the Dutch review ofGenX
>> (akaFRD-902orammonium
>> 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate):
DEQ-CFW-00049771

> https://www.ozhz.nl/fileadmin/uploads/Bedrijfdossiers Chemours/Bijlage 3 bij Kamerbrief
GenX rapport RIVM.PDF
>> They determined a NOAEL of 0.1 mg/kg/d in rodents and an RfD of0.084
>> ug/kg/day(or 84 ng/kg/day), based on combined uncertainty factors of
>> 1188.
>> "Overall, the following assessment factors are applied:
>> - Additional factor for potential kinetic difference 66
>> - Interspecies remaining toxicodynamic difference 1.8
>> - Intraspecies 10"
>> Not necessarily what we might have done in the US, but reasonable.
>> Based on risk assessment values that are standard in the US (2 L per
>> day water consumption, 70 kg body weight), one can calculate a
>> lifetime health advisory level of 0.6 - 2.3 ug/L (20% to 80% default
>> Relative Source Contribution). That is right on the edge of your
>> findings in the river water.
>> The rodent toxicology was conducted by DuPont and submitted several
>> years ago to USEPA, REACH in Europe and RIVM in the Netherlands.
>> Perry Cohn, PhD MPH
>> FYI, I am a retired NJDOH environmental epidemiologist,
>> 1990-2012 1 served ex-officio on the State commission,
>> Quality Institute, established in 1984 under amendments
>> Drinking Water Act to recommend drinking standards.
><Iittp://www.a,vg.com/einail-sigriatLire'?utm mediUm=email&utr11
email-&-u-t-rn co_ntent=emai1 client>
>> Virus -free. www.avg.com
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>> <#DAB4FAD8-2DD7-40BB-A1B8-4E2AA1F9FDF2>
and from
The Drinking Water
to our Safe
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Sent from my Android device with K-9 Mail. Please excuse my brevity.
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DEQ-CFW-00049772