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) x Intake (L/day))/Body weight (kg)]
�tration,
) x Body weight (kg))/Intake (L/day)]
mg/L DHHS issued a health advisory
ug/L for GenX of 7,909 ng/L on xxxx
ng/L
, David <[e-mail]>; Dittman, Elizabeth <[e-mail]>; Holt, Kennedy <Kennedy.F
pepper, Linda <[e-mail]>; Shehee, Mina <[e-mail]>
-isk assessments by other agencies and organizations. One goal has been to determine an appropriate point of d,
-equest in a few minutes.
information we have on the substances on p. vii. The NOAEL from the 28-day mouse study on p. viii is the POD
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nd based on similar effects observed in longer term studies, EPA intends to use a NOAEL of 0.1 mg/kg/day in its
intra-species variability and a 10-fold uncertainty factor for inter -species extrapolation resulting in a total uncert
nology by Chemours, Dordrecht. In this report, a NOAEL of 0.1 mg/kg/day from the oral chronic study in rats wa
)sition=inline)
>_28 days in duration, as reported by the submitter in the registration dossier.
es by an authorized State official. Unauthorized disclosure of juvenile, health, legally privileged, or otherwise confidential information, including confides
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[e-mail]>
eparture. The EPA shared the information below to help us address that goal.
used to set the occupational exposure level (called the New Chemical Exposure Limit (NCEL)). The discussion on
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re -assessment of GenX. This NOAEL (0.1 mg/kg/day) was determined in two separate mouse studies: repeated (
ainty factor of 100. EPA intends to use this same approach in conducting the re -assessment of GenX and its ass(
s selected as the point of departure (POD) for derivation of a chronic inhalation exposure limit. (Source: Evaluati
ntial information relating to an ongoing State procurement effort, is prohibited by law. If you have received this email in error, please notify the sender it
DEQ-CFW 00000322

i the NCEL starts on page 14. The NCEL value of 0.01mg/m3 is on p. 16. The derivation is given in the risk asses
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lose 28-day oral toxicity study in mice and oral reproduction/developmental toxicity screening study in mice. W
)ciated acid.
on of substances used in the GenX technology by Chemours, Dordrecht, RIVM letter report 2016-0174, M. Beekl
nmediately and delete all records of this email.
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sment but not in the consent order. Note that the risk assessment at the time did not look at gen pop exposure
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'hile the lowest NOAEL determined in the oral chronic toxicity/oncogenicity study in rats (1 mg/kg/day) is from a
,nan et al.
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because we did not believe we had releases. Thus, only the NCEL was set.
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study which employed a longer dosing duration, this NOAEL is higher than the NOAEL of 0.1 mg/kg/day from At
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idies in mice.
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