NC0001058_Permit (Modification)_20140617

�lCDENR
North Carolina Department of Environment and Natural Resources
Division of Water Resources
Pat McCrory John E. Skvada, III
Governor Secretary
June 17,2014
J.Wayne Powell
Patheon Manufacturing Service LLC
PO Box 1887
Greenville,NC 27835
Subject: NPDES Permit Modification-Name and/or
Ownership Change
Permit Number NC0001058
Patheon Manufacturing Services LLC
Pitt County
Dear Mr.Powell:
Division personnel have reviewed and approved your request to transfer ownership of the subject permit,received
on June 16,2014. This permit modification documents the change of ownership.
Please find enclosed the revised permit. All other terms and conditions contained in the original permit remain
unchanged and in full effect. This permit modification is issued under the requirements of North Carolina General
Statutes 143-215.1 and the Memorandum of Agreement between North Carolina and the U.S.Environmental Protection
Agency.
If you have any questions concerning this permit modification,please contact the Wastewater Branch at(919)
807-6304.
Since�ly,
• r
�u
Thomas A. Reeder
cc: Central Files
Washington Regional Office
NPDES Unit File
1617 Mail Service Center,Raleigh,North Carolina 27699-1617
Location:512 N.Salisbury St Raleigh,North Carolina 27604 One
Phone:[phone] FAX [phone] Customer Service:1-877-62M748 NofthCarolina
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An Equal Opportunity%Affirmative Action Empbyer

Permit NC0001058
STATE OF NORTH CAROLINA
DEPARTMENT OF ENVIRONMENT AND NATURAL RESOURCES
DIVISION OF WATER RESOURCES
PERMIT
TO DISCHARGE WASTEWATER UNDER THE
NATIONAL POLLUTANT DISCHARGE ELIMINATION SYSTEM
In compliance with the provision of North Carolina General Statute 143-215.1, other lawful standards
and regulations promulgated and adopted by the North Carolina Environmental Management
Commission,and the Federal Water Pollution Control Act,as amended,
Patheon Manufacturing Services LLC
is hereby authorized to discharge wastewater from a facility located at
Patheon Manufacturing Services LLC
U.S. Highway 13 North @ U.S. Highway 11 & 264 Bypass
Greenville
Pitt County
to receiving waters designated as Parkers Creek in the Tar-Pamlico River Basin in accordance with
effluent limitations, monitoring requirements, and other conditions set forth in Parts I, II, III, and IV
hereof.
This permit shall become effective June 17,2014.
This permit and authorization to discharge shall expire at midnight on October 31,2014.
Signed this day June 17,2014.
Th A. Reeder, Director
Division of Water Resources
By Authority of the Environmental Management Commission

Permit NC0001058
SUPPLEMENT TO PERMIT COVER SHEET
All previous NPDES Permits issued to this facility,whether for operation or discharge are hereby revoked.As of
this permit issuance, any previously issued permit bearing this number is no longer effective. Therefore, the
exclusive authority to operate and discharge from this facility arises under the permit conditions, requirements,
terms, and provisions included herein.
Patheon Manufacturing Services, LLC. is hereby authorized to:
1. Continue to discharge non-contact cooling water from a facility located at the Patheon
Manufacturing Services LLC facility, located near Greenville at the intersection of U.S. Highway 13
North and U.S. Highway 11 & 264 Bypass in Pitt County.
2. Discharge from said treatment works (via Outfall 001 and 002) into Parkers Creek, currently a class
C-NSW water in the Tar-Pamlico River Basin, at the location specified on the attached map.

Permit NC0001058
A. (1) EFFLUENT LIMITATIONS AND MONITORING REQUIREMENTS
Beginning on January 1, 2010 and lasting until expiration, the Permittee is authorized to discharge non-contact
cooling water from Outfall 001 and 002. Such discharges shall be limited acid monitored by the Permittee as
specified below:
EFFLUENT LIMITATIONS MONITORING REQUIREMENTS
PARAMETER
Monthly Daily Measurement Sample Sample
Average Maximum Frequency Type Location,
Flow Monthly Instantaneous Effluent
Total Residual Chlorine Monthly Grab Effluent
Temperature,°C 3 Monthly Grab Effluent
PH >6.0 and<9.0 standard units Monthly Grab Effluent
Footnotes:
1. Effluent monitoring requirements apply only if non-contact cooling water is discharged via Outfalls 001/002.
If non-contact cooling water is not discharged during a particular month,the permittee should write "No
Flow"on the submitted Discharge Monitoring Report(DMR). _
Effluent Sampling Point=Outlet of the cooling tower blowdown,prior to comingling with the other waste
streams.
2. TRC monitoring requirements apply only if chlorine is added to the cooling tower.
The Division shall consider all effluent TRC values reported below 50 ug/1 to be in compliance with the
permit. However,the Permittee shall continue to record and submit all values reported by a North Carolina
certified laboratory(including field certified),even if these values fall below 50 ug/l.
3. The temperature of the effluent shall not cause an increase in the temperature of the receiving stream of more
than 2.8°C,and in no case cause the ambient water temperature to exceed 32°C.
4. Ethylene glycol monitoring is imposed for the purpose of evaluating ethylene glycol discharges from this
facility and resulting impacts on the receiving waters. Upon petition from the permittee and at such time as
all sources of ethylene glycol discharges are eliminated or analytical data collected for a period of at least 2
years under the terms of this permit indicate no significant water quality concerns,the requirements for
ethylene glycol monitoring shall be evaluated and modified accordingly.
THERE SHALL BE NO DISCHARGE OF FLOATING SOLIDS OR VISIBLE FOAM IN OTHER THAN TRACE AMOUNTS.
A. (2) BIOCIDE CONDITION
There shall be no chromium,zinc or copper added to the treatment system except as pre-approved
additives to biocidal compounds.
The permittee shall obtain approval from the Division's Aquatic Toxicology Unit prior to the use of any
biocide(not previously approved by the Division) in the effluent discharged under this permit.
Approval for use of any biocide not previously approved should be requested at least 90 days in advance
of any planned usage.
Contact the Aquatic Toxicology Unit for detailed instructions on requesting approval of biocides:
NC DENR/DWR/Aquatic Toxicology Unit
1621 Mail Service Center
Raleigh,North Carolina 27699-1621

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Patheon Manufacturing Services LLC LOCATION
(not to scale)
Coun Pitt Stream Class: C-NSW
Receivine Stream: Parker Creek Sub-Basin: 030305
Latitude: 35°39'24" Grid/Quad: E29NE
Loneitude: 770 21'24" North IFNPDES Permit No. NC0001058

State of North Carolina
Department of Environment RECEIVED/^ENR/DWR
A• •
and Natural Resources
Division of Water Resources JUN 6 ZG i4
Pat McCrory, Governor Water Quality D E R
John E. Skvarla III, Secretary permitting Section
Thomas A. Reeder, Director
PERMIT NAME/OWNERSHIP CHANGE FORM
I. CURRENT Permit Information:
Permit Number(s): i.e. NC0012345 orNCG500123 NC0001058
Permit Holder's Name: Jerry Wayne Powell
Facility Name: DSM Pharmaceuticals, Inc.
H. NEW Owner/Name Information:
1. This request for a name change is a result of:
® a. Change in ownership of property/compady
❑ b. Name change only Q
❑ c. Other(please explain): JUN 0 610 i4
2. New owner's name(name to be put on permit):
` Patheon Manufacturing Services LLC 1
3. New owner's or signing official's name and title(Person legally responsible for permit):
J.Wayne Powell
Name
Senior Environmental Manager
Title
4. Mailing Address:
Address: Patheon Manufacturing Services LLC,PO Boz 1887
City: Greenville State: NC Zip: 27835-1887
Telephone#: [phone] Cell#: 252-717-5159
Email: wayne.powell@dsnuwm
1617 Mail Service Center,Raleigh,North Carolina 27699-1617 Telephone(919)W74OW FAX(919)W-M
An Eclual Opportunity Affirmative Action Employer 50%recycled 110%post-consumer paper

THIS APPLICATION PACKAGE WILL NOT BE ACCEPTED BY THE DIVISION UNLESS
ALL OF THE APPLICABLE ITEMS LISTED BELOW ARE INCLUDED WITH THE
SUBMITTAL.
REQUIRED ITEMS:
1. This completed application form
2. Legal documentation of the transfer of ownership
(property deed articles of incorporation, or sales agreement)
CERTIFICATION:
I,Jerry Wayne Powell,attest that this application for a name/ownership change has been reviewed and
is accurate and complete to the best of my knowledge. I understand that if all required parts of this
application are not completed and that if all required supporting information and attachments are not
included,this application package will be returned as incomplete.
ASignature: Date: June 3.2014
THIS COMPLETED APPLICATION PACKAGE,
INCLUDING ALL SUPPORTING INFORMATION& MATERIALS,
SHOULD BE SENT TO THE FOLLOWING ADDDRESS:
NC DENR/DWR/WQ Permitting Section
1617 Mail Service Center
Raleigh,North Carolina 27699-1617
mpk/Revised 911113

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Doc ID: 012289020004 Type: CRP
Recorded: 03/070%14 at 02:13:30 PM
Fee Amt: 2628.00 Pape 1 of 4
Revenue Tax: 60.00
Pitt County, NC
Lisa P. Nichols REG OF DEEDS
3202 Pal-4
NORTH CAROLINA GENERAL WARRANTY DEED
Excise Tax:-0-
Parcel identifier Nos.Out of 4780803677;4689889838;4790007772;4790120208;4780835112 Verified by County
on the day of ,20
By:
Mail/Box to:Grantee
This instrument was prepared by:Smith,Anderson,Blount,Dorsett,Mitchel&Jernigan,L.L.P.,(MRT),P.O.Box 2611,Raleigh,
North Carolina 27602-2611
Brief description for the Index: 143.53 acres New Lot 2 Map Book 77 Page51��— Greenville Township
THIS DEED made this day of March,2014,by and between
GRANTOR GRANTEE
DSM Pharmaceuticals,Inc.,a Delaware corporation, DPI Newco LLC,a Delaware limited liability
successor by merger with Catalytica Pharmaceuticals,Inc.,a company
Delaware corporation 5900 Martin Luther King Jr. Highway
5900 Martin Luther King Jr.Highway Greenville,North Carolina 27835-0000
Greenville,North Carolina 27835-0000
Enter in appropriate block for each Grantor and Grantee: name,mailing address,and,if appropriate,character of entity,e.g.
corporation or partnership.
The designation Grantor and Grantee as used herein shall include said parties,their heirs,successors,and assigns,and shall include
singular,plural,masculine,feminine or neuter as required by context.
WITNESSETH,that the Grantor,for a valuable consideration paid by the Grantee,the receipt of which is hereby acknowledged,has and
by these presents does grant,bargain,sell and convey unto the Grantee in fee simple,all that certain lot,parcel of land or condominium
unit situated in the City of Greenville,Greenville Township,Pitt County,North Carolina and more particularly described as follows:
All that certain tract or parcel of land designated as New Lot 2 as shown on plat of survey entitled"DSM Pharmaceuticals Inc.
Exempt Subdivision and Minor Alteration Plat" prepared by John A. Edwards & Company Consulting Engineers dated
February 17,2014 and recorded March *1 '�2014 in Map Book -7 ,Pag /.?&-41 itt County Registry.
0 Nc General Warranty Deed Nc Bar Form 2013 Dpi Newco Uc(2)Bar Association Form No.3®1976,Revised®1/1/2010,2013 This
standard form has been approved by:
Printed by Agreement with the NC Bar Association North Carolina Bar Association—NC Bar Form No.3

The property hereinabove described was acquired by Grantor by instrument recorded in Book 746 page 821.
All or a portion of the property herein conveyed_includes or X_does not include the primary residence of a Grantor.
A map showing the above described property is recorded in Plat Book page
TO HAVE AND TO HOLD the aforesaid lot or parcel of land and all privileges and appurtenances thereto belonging to the Grantee in
fee simple.
And the Grantor covenants with the Grantee,that Grantor is seized of the premises in fee simple,has the right to convey the same in fee
simple,that title is marketable and free and clear of all encumbrances,and that Grantor will warrant and defend the title against the
lawful claims of all persons whomsoever,other than the following exceptions:
SEE EXHIBIT A ATTACHED HERETO AND MADE A PART HEREOF.
IN WITNESS WHEREOF,the Grantor has duly executed the foregoing as of the day and year first above written.
DSM PHARMACEUTICALS.INC.
By:
Print/Type Name&Title:Hugh C.Welsh,President
Stated NUvS U S4 -Countyor Cityof tyi7
1,the undersignad Notary Public of the County or City of and State aforesaid,certify that
Hugh C.Welsh personally came before me this day and acknowledged that he is the President of DSM Pharmaceuticals,Inc.,a
Delaware corporation successor by merger with Catalytica Pharmaceuticals,Inc.,a Delaware corporation,and that by authority
duly given and as the act of such entity,he signed the foregoing instrument in its name on its behalf as its act and deed. Witness
my hand and Notarial stamp or seal,this day of March,2014.
Y p U G�. 'a�,`c�4 b TC16%J Notary M Commission Expires: et• N til Nota Public
(Affix Stamp or Seal) Notary's Printed or Typed Name
� '��• y ' LORRAINE M. DANZITI
a .•. AA__
Notary Public.State of New Jersey
My Commission Expires
October 22, 2018
. mss••. p,;�,�: � ;�
F/%••••• ••• 1•�= S;pVn to and subsolled
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2
NC Bar Association Form No.3®1976,Revised®1/1/2010,2013 This standard form has been approved by-
Printed
yPrinted by Agreement with the NC Bar Association North Carolina Bar Association—NC Bar Form No.3

EXHIBIT A
PERMITTED EXCEPTIONS
1. Taxes or assessments for the year 2014, and subsequent years, not yet due or payable.
2. Any discrepancy,conflict,access,shortage in area or boundary lines, encroachment, encumbrance,violation,
variation,overlap, setback,easement or claims of easement, riparian right, and title to land within roads,ways,
railroads,watercourses, burial grounds, marshes, dredged or filled areas or land below the mean highwater mark
or within the bounds of any adjoining body of water, or other adverse circumstance affecting the Title that would be
disclosed by a current inspection and accurate and complete land survey of the Land.
3. Rights of others in and to the continuous and uninterrupted flow of the waters bounding or crossing the Land and
riparian and/or littoral rights Incident to the Land.
4. All land use and environmental control rules, regulations, and statutes now in effect established by governmental
agencies affecting the Land.
5. Title to that property lying within the bounds of any public street, road, highway,or railroad crossing Insured Land.
6. Any right,easement, setback, Interest, claim,encroachment, encumbrance,violation,variations or other adverse
circumstance affecting the Title disclosed by plat(s)recorded in Map Book 18, Pages 1 and 1A;Map Book 10,
Page 138; Book J-50, Page 396; and Map Book 48, Page 143.
7, Use restriction(s)contained in the deeds recorded in Book H-38, page 410; Book H-38, Page 579; Book H28,
Page 417 and Book H-38, Page 438; Book H-38, Page 456; and Book J-38, Page 144 and Book Y-38, Page 96.
8. Right(s)of way to Carolina Telephone and Telegraph Company recorded In Book X-17, page 161.
9. Permit(s)to Carolina Telephone and Telegraph Company recorded in Book L-30, page 218.
10. Permit(s)to Carolina Telephone and Telegraph Company recorded in Book U-27, page 19;and Book Y-32,page
571.
11. Permit(s)to Carolina Telephone and Telegraph Company recorded in Book M-19, page 177.
12. Permit(s)to Carolina Telephone and Telegraph Company recorded in Book J-25, page 71.
13. Permits)to Carolina Telephone and Telegraph Company recorded in Book 0-23, page 317.
14. Permit(s)to Carolina Telephone and Telegraph Company recorded in Book M-19, page 174; Book A-22, page
571; Book J-25, page 64; and Book K-26, page 313.
15. Easement(s)to the City of Greenville for the use of Greenville Utilities Commission recorded in Book U-44, page
190.
16. Easement(s)to the City of Greenville for the use of Greenville Utilities Commission recorded in Book 377,page
99.
17. Easement(s)to the City of Greenville for the use of Greenville Utilities Commission recorded in Book 255, page
37.
18. Easement(s)to the City of Greenville for the use of Greenville Utilities Commission recorded in Book 5-38, page
232.
3
NC Bar Association Form No.3®1976,Revised O 1/1/2010.2013 This standard form has been approved by:
Printed by Agrecmcnt with the NC Bar Association North Carolina Bar Association—NC Bar Form No.3

19. Easement(s)and Right(s)of Way to the City of Greenville for the use of Greenville Utilities Commission recorded
In Book A-40, page 638.
20. Easement(s)to the City of Greenville for the use of Greenville Utilities Commission recorded in Book 130,page
365.
21. Grant of Access Easement(s)to the City of Greenville for the use of Greenville Utilities Commission recorded in
Book 265,page 534.
22. Correction of Grant of Access Easement(s)to the City of Greenville for the use of Greenville Utilities Commission
recorded in Book 317, page 373.
23. Easement(s)and Right(s)of Way to the City of Greenville recorded in Book M40, page 278.
24. Temporary Deed of Easement between Catalytica Pharmaceuticals, Inc.and Glaxo Wellcome, Inc.,recorded in
Book 746,page 858.
25. Rights of tenants in possession,as tenants only, under unrecorded leases for a duration of less than three(3)
years.
26. Stormwater Maintenance Plan by and between DSM Pharmaceuticals, Inc. and the City of Greenville recorded
June 22,2009 in Book 2640, page 832.
27. Title to any portion of the Land lying within the right of way of US Hwy.264 Right of Way Interchange;Variable
Width Public Right of Way of NC Hwy. 11 and US Hwy 13; Variable Width Public Right of Way of NC Hwy.903;
and Variable Width Public Right of Way of Martin Luther King Jr. Hwy.
4
NC Bar Association Form No.3 01976,Revised®1/117010,2013 This standard form has been approved by.
Printed by Agroeme
nt with the NC Bar Association North Carolina Bar Association—NC Bar Form No.3

• DSM
• BRIGHT SCIENCE.BRIGHTER LIVING.
DSM Pharmaceuticals, Inc.
June 3, 2014
NC DENR
DWR/WQ Permitting Section
1617 Mail Service Center
Raleigh, NC 27699-1617
Subject: Permit Name/Ownership Change Request
Dear Sir/Madam,
Please find attached, a Permit Name/Ownership Change Form to change the ownership of NC0001058 to
Patheon Manufacturing Services LLC. The Ownership Change is applicable to New Lot 2 on the attached
plat. The DSM Greenville site has been divided as a result of a merger.
If you need any additional information please contact me at (252)-707-2310.
Sincerely,
06
l 'l
iane P ell
Senior Environmental Manager
Enclosure
HEALTH • NUTRITION• MATERIALS