NC0001058_Renewal (Application)_20240205

ROY COOPER
Governor
ELIZABETH S. BISER
Secretary
RICHARD E. ROGERS, JR.
Director
Natalie Brown
Patheon Manufacturing Services LLC
PO Box 1887
Greenville, NC 27834-1887
Subject: Permit Renewal
Application No. NC0001058
Patheon Manufacturing Services
Pitt County
Dear Applicant:
NORTH CAROLINA
Environmental Quality
February 05, 2024
The Water Quality Permitting Section acknowledges the February 5, 2024 receipt of your permit renewal application and
supporting documentation. Your application will be assigned to a permit writer within the Section's NPDES WW permitting
branch. Per G.S. 150B-3 your current permit does not expire until permit decision on the application is made.
Continuation of the current permit is contingent on timely and sufficient application for renewal of the current permit. The
permit writer will contact you if additional information is required to complete your permit renewal. Please respond in a
timely manner to requests for additional information necessary to allow a complete review of the application and renewal
of the permit.
Information regarding the status of your renewal application can be found online using the Department of Environmental
Quality's Environmental Application Tracker at:
https://deg.nc.gov/permits-regulations/permit-guidance/environmental-application-tracker
If you have any additional questions about the permit, please contact the primary reviewer of the application using the
links available within the Application Tracker.
Sincerely,
Cynthia Demery
Administrative Assistant
Water Quality Permitting Section
ec: WQPS Laserfiche File w/application
D_E QQ)North Carolina Department of Environmental Quality I Division of Water Resources
Washington Regional Office 1 943 Washington Square Mall I Washington North Carolina 27889
252.946.6481

Thermo Fisher
S C I E N T I F I C
February 1, 2024
Laseriici�e
Thermo Fisher Scientific
5900 Martin Luther King Jr. Highway
Greenville, NC 27834
[phone]
www.thermofisher.com
RECEIVED
NCDEQ FEB 0 5 2024
Division of Water Quality / NPDES Unit
1617 Mail Service Center NCDEQ/DWR/NPDES
Raleigh, NC 27699-1617
Subject: Renewal Application for Patheon Manufacturing Services LLC
Patheon Manufacturing Services, LLC is submitting a renewal request for their NPDES
permit NC0001058. This permit is for the non -contact cooling water blowdown at the
Patheon site. Please find the attached original and two copies required for renewal,
along with supporting documentation.
If you need any additional information please contact me at (252-714-1792) or via email
at [e-mail]
Sincerely,
R. Hunter Copeland
Senior Mgr EHS
Pharma Services
Patheon, part of Thermo Fisher Scientific

EPA Identification Number
NPDES Permit Number
Facility Name
Form Approved 03/05/19
NCD047375766
NCO01058
Patheon Manufacturing Services
OMB No. 2040-0004
Form
U.S. Environmental Protection Agency
t
\" EPA
Application for NPDES Permit to Discharge Wastewater
NPDES
GENERAL INFORMATION
SECTION•NPDES
Applicants Not Required to Submit Form 1
1.1
1.1.1
Is the facility a new or existing publicly owned
1 1 2
Is the facility a new or existing treatment works
treatment works?
treating domestic sewage?
If yes, STOP. Do NOT complete [� No
If yes, STOP. Do NOT 0 No
Form 1. Complete Form 2A.
complete Form 1. Complete
Form 2S.
1.2
Applicants Required to Submit Form 1
1.2.1
Is the facility a concentrated animal feeding
1.2.2
Is the facility an existing manufacturing,
operation or a concentrated aquatic animal
commercial, mining, or silvicultural facility that is
a
production facility?
currently discharging process wastewater?
oYes
4 Complete Form 1 No
✓� Yes 4 Complete Form No
a
and Form 2B.
1 and Form 2C.
1.2.3
Is the facility a new manufacturing, commercial,
1.2.4
Is the facility a new or existing manufacturing,
mining, or silvicultural facility that has not yet
commercial, mining, or silvicultural facility that
—
commenced to discharge?
discharges only nonprocess wastewater?
Cr
Yes -+ Complete Form 1 ❑ No
❑ Yes -+ Complete Form No
and Form 2D.
1 and Form 2E.
W
.°—:
1.2.5
Is the facility a new or existing facility whose
'—
discharge is composed entirely of stormwater
a
associated with industrial activity or whose
discharge is composed of both stormwater and
non-stormwater?
❑ Yes -+ Complete Form 1 ✓❑ No
and Form 2F
unless exempted by
40 CFR
122.26(b)(14)(x) or
b )(15).
SECTIONDD-
• •
Facility Name
2.1
Patheon Manufacturing Servicess LLC
0
2.2
EPA Identification Number
R
U
o
J
Hazardous Waste (RCRA) NCD047375766
r
2.3
Facility Contact
Name (first and last)
Title
Phone number
R. Hunter Copeland
Sr. Manager EHS
[phone]
Q
Email address
c
[e-mail]
2.4
Facility Mailing Address
E
Street or P.O. box
z
5900 Martin Luther King Jr Highway
City or town
State
ZIP code
Greenville
North Carolina
27834
EPA Form 3510-1 (revised 3-19) Page 1

EPA Identification Number
NPDES Permit Number
Facility Name
Form Approved 03/05/19
NCD047375766
NCO01058
Patheon Manufacturing Servic1
OMB No. 2040-0004
2.5
Facility Location
.y
Street, route number, or other specific identifier
Q 0
5900 Martin Luther King Jr Highway
a o
County name
County code (if known)
c
Pitt
us
E a
City or town
State ZIP code
z m
Greenville
North Carolina 27834
SECTION1
NAICS CODES
SIC Code(s)
Description (optional)
3.1
2833
Medicinal Chemicals and Botanical Products
2834
Pharmaceutical Preparations
m
0
0
U
U)
U
Z
3.2
NAICS Code(s)
Description (optional)
r
cc
325412
Pharmaceutical Preparation Manufacturing
U
325411
Medicinal and Botanical Manufacturing
Name of 0 erator
4.1
R. Hunter Copeland
`o_
4.2
Is the name you listed in Item 4.1 also the owner?
CU
E
❑ Yes ❑✓ No
0
4.3
Operator Status
❑ Public —federal ❑ Public —state ❑ Other public (specify)
❑✓ Private ❑ Other (specify)
4.4
Phone Number of Operator
[phone]
4.5
Operator Address
Street or P.O. Box
E y
5900 Martin Luther King Jr Highway
City or town
State
ZIP code
`o o
Greenville
North Carolina
27834
� U
a
Email address of operator
O
[e-mail]
SECTION1
5.1
I `I
Is the facility located on Indian Land?
c
c
❑ Yes ❑✓ No
EPA Form 3510-1 (revised 3-19) Page 2

EPA Identification Number NPDES Permit Number Facility Name Form Approved 03/05/19
NCD047375766 NCO01058 Patheon Manufacturing Serviceb OMB No. 2040-0004
iECTION 6. EXISTING ENVIRONMENTAL1
6.1 Existing Environmental Permits (check all that apply and print or type the corresponding permit number for each)
cc
d m NPDES (discharges to surface ❑ RCRA (hazardous wastes) ❑ UIC (underground injection of
o y water) fluids)
NCO01058 NCD047373766-R2
w ❑ PSD (air emissions) ❑ Nonattainment program (CAA) ❑ NESHAPs (CAA)
w El Ocean dumping (MPRSA) El Dredge or fill (CWA Section 404) ✓❑ Other (specify)
Svnthetic Minor Air 10634R01
7.1 Have you attached a topographic map containing all required information to this application? (See instructions for
specific requirements.)
Yes ❑ No ❑ CAFO—Not Applicable (See requirements in Form 2B.)
8.1 1Describe the nature of your business.
Pharmacuetical Manufacturing
w
H
N
C
7
133
w
O
N
3
a+
R
Z
9.1 Does your facility use cooling water?
d ❑ Yes ❑✓ No -* SKIP to Item 10.1.
c ' 9.2 Identify the source of cooling water. (Note that facilities that use a cooling water intake structure as described at
' 40 CFR 125, Subparts I and J may have additional application requirements at 40 CFR 122.21(r). Consult with your
Cn
NPDES permitting authority to determine what specific information needs to be submitted and when.)
O Y
U
0) 110.1 Do you intend to request or renew one or more of the variances authorized at 40 CFR 122.21(m)? (Check all that
apply. Consult with your NPDES permitting authority to determine what information needs to be submitted and
when.)
Cr d ❑ Fundamentally different factors (CWA ❑ Water quality related effluent limitations (CWA Section
Section 301(n)) 302(b)(2))
❑ Non -conventional pollutants (CWA ❑ Thermal discharges (CWA Section 316(a))
Section 301(c) and (g))
❑✓ Not applicable
EPA Form 3510-1 (revised 3-19) Page 3

EPA Identification Number
NPDES Permit Number
Facility Name Form Approved 03/05/19
NCD047375766
NCO01058
Patheon Manufacturing Service IIJ OMB No. 2040-0004
SECTION•
1
In Column 1 below, mark the sections of Form 1 that you have completed and are submitting with your application.
11.1
For each section, specify in Column 2 any attachments that you are enclosing to alert the permitting authority. Note
that not all applicants are required to provide attachments.
Column 1
Column 2
❑✓ Section 1: Activities Requiring an NPDES Permit
❑ wl attachments
❑✓ Section 2: Name, Mailing Address, and Location
❑ w/ attachments
✓❑ Section 3: SIC Codes
❑ w/ attachments
✓❑ Section 4: Operator Information
❑ w/ attachments
❑✓ Section 5: Indian Land
❑ w/ attachments
❑✓ Section 6: Existing Environmental Permits
❑ w/ attachments
c
E
�;
❑✓ Section 7: Map
w/ topographic
❑✓ Elw/ additional attachments
�a
map
r
c
❑✓ Section 8: Nature of Business
Elw/ attachments
w
✓❑ Section 9: Cooling Water Intake Structures
❑ w/ attachments
�'
-o
✓❑ Section 10: Variance Requests
❑ wl attachments
�_
✓❑ Section 11: Checklist and Certification Statement
Elw/ attachments
Y
d
11.2
Certification Statement
s
U
1 certify under penalty of law that this document and all attachments were prepared under my direction or supervision
in accordance with a system designed to assure that qualified personnel properly gather and evaluate the
information submitted. Based on my inquiry of the person or persons who manage the system, or those persons
directly responsible for gathering the information, the information submitted is, to the best of my knowledge and
belief, true, accurate, and complete. I am aware that there are significant penalties for submitting false information,
including the possibility of fine and imprisonment for knowing violations.
Name (print or type first and last name)
Official title
R. Hunter Copeland
Senior Mgr EHS
Signature
Date signed
2 . ��, cr-y ,
2I I z�
EPA Form 3510-1 (revised 3-19) Page 4

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OUTFALL
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a. REENQUJLE
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Patheon Manufacturing Services LLC
County:
Pitt Stream Class: C•NSW
ReceivineStrtream:
Parker Creek Sub -Basin: 03-03-05
Latitude (001):
35039' 30" USGS Quad: Grecavillc NE
Lonaitude (001):
77.21' 29"
Latitude (002):
35. 39' 20"
Loneitude (002):
7r 21' 24"
FACRATY
LOCATION x
(not to scale)
•/�l � NPDES Permit NC0001058

EPA Identification Number NPDES Permit Number Facility Name Form Approved 03/05/19
NCD047373766-R2 NCO01058 Patheon Manufacturing Services OMB No. 2040-0004
Form U.S. Environmental Protection Agency
2C EPA Application for NPDES Permit to Discharge Wastewater
NPDES EXISTING MANUFACTURING, COMMERCIAL, MINING, AND SILVICULTURE OPERATIONS
SECTIONOUTFALL LOCATION
1.1 Provide information on each of the facility's outfalls in the table below.
Numbelr Receiving Water Name Latitude Longitude
U
0 001 Parker Creek 35' 39' 30" N 77' 2V 29" W
002 Parker Creek 35' 39' 20" N 77° 21' 24" W
O
SECTIOND' 1
a, 2.1 Have you attached a line drawing to this application that shows the water flow through your facility with a water
.3 balance? (See instructions for drawing requirements. See Exhibit 2C-1 at end of instructions for example.)
J c6
o ✓❑ Yes ❑ No
SECTION•
3.1 For each outfall identified under Item 1.1, provide average flow and treatment information. Add additional sheets if
necessary.
**Outfall Number'* 001
Operations
Operation Average Flow
Cooling Tower Blowdown 0.0132 mgd
E mgd
M
mgd
Z
cc
y mgd
3
0 Treatment Units
U.
Q, Description Code from Final Disposal of Solid or
a (include size, flow rate through each treatment unit, Table 2C 1 Liquid Wastes Other Than
a retention time, etc.) by Discharge
Summertime average 15 gpm with dosing at approx 2E
30 ppm for each tower
EPA Form 3510-2C (Revised 3-19) Page 1

EPA Identification Number
NPDES Permit Number
Facility Name
Form Approved 03/05/19
NCD047373766-R2
NCO01058
Patheon Manufacturing Services
OMB No. 2040-0004
3.1
**Outfall Number** 002
Cont.
Operations
Operation
Average Flow
Cooling Tower Blowdown
0.097 mgd
mgd
mgd
mgd
Description
Code from
Final Disposal of Solid or
(include size, flow rate through each treatment unit,
Table 2C-1
Liquid Wastes Other Than
retention time, etc.)
by Dischar e
Summertime average 15gpm with dosing at approx
2E
c
30 ppm for each tower
0
U
c
m
E
ie
m
H
**Outfall Number**
0
Operations Contributing to Flow
Operation
Average Flow
o
LL
mgd
d
a'
mgd
mgd
mgd
Treatment
Description
Units
Code from
Final Disposal of Solid or
(include size, flow rate through each treatment unit,
Table 2C-1
Liquid Wastes Other Than
retention time, etc.)
by Dischar e
3.2
Are you applying for an NPDES permit to operate a privately owned treatment works?
0
❑ Yes ✓❑ No 4 SKIP to Section 4.
ND
3.3
Have you attached a list that identifies each user of the treatment works?
❑ Yes ❑ No
EPA Form 3510-2C (Revised 3-19) Page 2

EPA Identification Number NPDES Permit Number Facility Name Form Approved 03/05/19
NCD047373766-R2 NCO01058 Patheon Manufacturing Services OMB No. 2040-0004
SECTION• 1
4.1 Except for storm runoff, leaks, or spills, are any discharges described in Sections 1 and 3 intermittent or seasonal?
❑✓ Yes ❑ No 4 SKIP to Section 5.
4.2
Provide information
on intermittent or seasonal flows for each applicable outfall. Attach additional pages, if n cessary.
Freq
uency
Flow
Rate
Outfall
Operation
Duration
Average
Average
Long -Term
Maximum
Number
(list)
Da sMeek
MonthsNear
Average
Dail
Cooling Tower Blowdov
7 days/week
12 months/year
.00004 mgd
0.0017 mgd
365 days
0
001
days/week
months/year
mgd
mgd
days
U_
c
days/week
months/year
mgd
mgd
days
aD
E
Cooling Tower Blowdo
1 days/week
12 months/year
.00005 mgd
0.0001 mgd
365 days
m
c
days/week
months/year
mgd
mgd
days
002
days/week
months/year
mgd
mgd
days
days/week
months/year
mgd
mgd
days
days/week
months/year
mgd
mgd
days
days/week months/year mgd mgd days
SECTION"•D
• 1
5.1
Do any effluent limitation guidelines (ELGs) promulgated by EPA under Section 304 of the CWA apply to your facility?
✓❑ Yes ❑ No 4 SKIP to Section 6.
5.2
Provide the following information on applicable ELGs.
ELG Category
ELG Subcategory
Regulatory Citation
w
m
Pharmaceutical Manufacturing
Mixing/Compounding and Formulation
40 CFR Prt 439 Subpart D
U
Q
Q
Q
5.3
Are any of the applicable ELGs expressed in terms of production (or other measure of operation)?
❑ Yes ✓❑ No 4 SKIP to Section 6.
0
%
5.4
Provide an actual measure of daily production expressed in terms and units of applicable ELGs.
J
Outfa
Operation, Product, or Material
Quantity per Day
Unit
-�
Number
r
Measure
m
c
o
-o
0
a
EPA Form 3510-2C (Revised 3-19) Page 3

EPA Identification Number NPDES Permit Number Facility Name Form Approved 03/05/19
NCD047373766-R2 NCO01058 Patheon Manufacturing Services OMB No. 2040-0004
SECTION'• 1
6.1 Are you presently required by any federal, state, or local authority to meet an implementation schedule for constructing,
upgrading, or operating wastewater treatment equipment or practices or any other environmental programs that could
affect the discharges described in this application?
❑ Yes ❑✓ No 4 SKIP to Item 6.3.
6.2
Briefly identify each applicable project in the table below.
Affected
Final Compliance Dates
E
Brief Identification and Description of
Outfalls
Source(s) of
o
Project
(list outfall
Discharge
Required
Projected
a
number
E
N
d
f6
CL
Q
6.3
Have you attached sheets describing any additional water pollution control programs (or other environmental projects
that may affect your discharges) that you now have underway or planned? (optional item)
❑ Yes ❑ No ✓❑ Not applicable
SECTIONi
See the instructions to determine the pollutants and parameters you are required to monitor and, in turn, the tables you must
complete. Not all applicants need to complete each table.
Table A. Conventional and Non -Conventional Pollutants
7.1
Are you requesting a waiver from your NPDES permitting authority for one or more of the Table A pollutants for any of
your outfalls?
❑ Yes ❑✓ No 4 SKIP to Item 7.3.
7.2
If yes, indicate the applicable outfalls below. Attach waiver request and other required information to the application.
Outfall Number Outfall Number Outfall Number
7.3
Have you completed monitoring for all Table A pollutants at each of your outfalls for which a waiver has not been
N
requested and attached the results to this application package?
0 Yes ❑ No; a waiver has been requested from my NPDES
permitting authority for all pollutants at all outfalls.
Table B.
Toxic Metals, Cyanide, Total Phenols, and Organic Toxic Pollutants
7.4
Do any of the facility's processes that contribute wastewater fall into one or more of the primary industry categories
listed in Exhibit 2C-3? (See end of instructions for exhibit.)
❑ Yes ✓❑ No 4 SKIP to Item 7.8.
7.5
Have you checked "Testing Required" for all toxic metals, cyanide, and total phenols in Section 1 of Table B?
W
❑ Yes ✓❑ No
7.6
List the applicable primary industry categories and check the boxes indicating the required GC/MS fraction(s) identified
in Exhibit 2C-3.
Primary Industry Category
Required GC/MS Fraction(s)
Check applicable boxes.
Pharmaceutical Preparations
t] Volatile E1 Acid 0 Base/Neutral ❑ Pesticide
❑ Volatile ❑ Acid ❑ Base/Neutral ❑ Pesticide
❑ Volatile ❑ Acid ❑ Base/Neutral ❑ Pesticide
EPA Form 3510-2C (Revised 3.19) Page 4

EPA Identification Number
NPDES Permit Number
Facility Name
Form Approved 03/05/19
NCDO47373766-R2
NCOO1O58
Patheon Manufacturing Services
iir
OMB No. 2040-0004
7.7
Have you checked "Testing Required" for all required pollutants in Sections 2 through 5 of Table B for each of the
GC/MS fractions checked in Item 7.6?
❑ Yes ❑✓ No
7.8
Have you checked 'Believed Present" or "Believed Absent" for all pollutants listed in Sections 1 through 5 of Table B
where testing is not required?
0 Yes ❑ No
7.9
Have you provided (1) quantitative data for those Section 1, Table B, pollutants for which you have indicated testing is
required or (2) quantitative data or other required information for those Section 1, Table B, pollutants that you have
indicated are `Believed Present' in your discharge?
0 Yes ❑ No
7.10
Does the applicant qualify for a small business exemption under the criteria specified in the instructions?
❑ Yes 4 Note that you qualify at the top of Table B, ❑ No
then SKIP to Item 7.12.
'c
7.11
Have you provided (1) quantitative data for those Sections 2 through 5, Table B, pollutants for which you have
c
determined testing is required or (2) quantitative data or an explanation for those Sections 2 through 5, Table B,
pollutants you have indicated are "Believed Present' in your discharge?
✓❑ Yes ❑ No
Table C. Certain Conventional and Non -Conventional Pollutants
7.12
Have you indicated whether pollutants are "Believed Present' or "Believed Absent' for all pollutants listed on Table C
r
for all outfalls?
Y
✓❑ Yes ❑ No
c
7.13
Have you completed Table C by providing (1) quantitative data for those pollutants that are limited either directly or
indirectly in an ELG and/or (2) quantitative data or an explanation for those pollutants for which you have indicated
"Believed Present'?
d
❑✓ Yes ❑ No
w
Table D. Certain Hazardous Substances and Asbestos
7.14
Have you indicated whether pollutants are 'Believed Present' or `Believed Absent' for all pollutants listed in Table D for
all outfalls?
✓❑ Yes ❑ No
7.15
Have you completed Table D by (1) describing the reasons the applicable pollutants are expected to be discharged
and (2) by providing quantitative data, if available?
❑✓ Yes ❑ No
Table E. 2,3,7,8-Tetrachlorodibenzo- -Dioxin 2,3,7,8-TCDD
7.16
Does the facility use or manufacture one or more of the 2,3,7,8-TCDD congeners listed in the instructions, or do you
know or have reason to believe that TCDD is or may be present in the effluent?
❑ Yes 4 Complete Table E. ❑✓ No 4 SKIP to Section 8.
7.17
Have you completed Table E by reporting qualitative data for TCDD?
❑ Yes ✓❑ No
SECTIONOR
MANUFACTURED TOXICS
Is any pollutant listed in Table B a substance or a component of a substance used or manufactured at your facility as
8.1
an intermediate or final product or byproduct?
3
❑ Yes ✓❑ No 4 SKIP to Section 9.
u
m
8.2
List the pollutants below.
c
1. 4. 7.
0
2. 5. 8.
F3, 6. 9.
EPA Form 3510-2C (Revised 3-19) Page 5

EPA Identification Number NPDES Permit Number Facility Name Form Approved 03/05/19
NCD047373766-R2 NCOO1058 Patheon Manufacturing Services OMB No. 2040-0004
SECTION• • • 1
9.1 Do you have any knowledge or reason to believe that any biological test for acute or chronic toxicity has been made
within the last three years on (1) any of your discharges or (2) on a receiving water in relation to your discharge?
❑ Yes ❑✓ No 4 SKIP to Section 10.
U)
9.2
Identify the tests and their
Durposes below.
Test(s)
Purpose of Test(s)
Submitted to NPDES
Date Submitted
X
Permitting Authority?
0
❑ Yes ❑ No
0
0
m
❑ Yes ❑ No
❑ Yes ❑ No
SECTIONi
CONTRACT
ANALYSES (40
Were any of the analyses reported in Section 7 performed by a contract laboratory or consulting firm?
10.1
❑ Yes ❑✓ No 4 SKIP to Section 11.
10.2
Provide information for each contract laboratory or consulting firm below.
Laboratory Number 1
Laboratory Number 2
Laboratory Number 3
Name of laboratory/firm
21
Laboratory address
a
U
l0
C
0
Phone number
Pollutant(s) analyzed
SECTIONDD
• •- •
Has the NPDES permitting authority requested additional information?
11.1
❑ Yes ✓❑ No + SKIP to Section 12.
0
11.2
List the information requested and attach it to this application.
`0
1. 4.
0
0
a
2. 5.
>3
a
3. 6.
EPA Form 3510-2C (Revised 3-19) Page 6

EPA Identification Number I NPDES Permit Number Facility Name I Form Approved 03/05/19
NCD0473-) R2 NCO01058 Patheon Manufacturing Services OMB No. 2040-0004
SECTION•
12.1
1
In Column 1 below, mark the sections of Form 2C that you have completed and are submitting with your application.
For each section, specify in Column 2 any attachments that you are enclosing to alert the permitting authority. Note
that not all applicants are required to com lete all sections or provide attachments.
Column 1
Column 2
✓❑ Section 1: Outfall Location
❑ w/ attachments
✓❑ Section 2: Line Drawing
✓❑ w/ line drawing ❑ w/ additional attachments
Section 3: Average Flows and
0
w/ list of each user of
❑ w/ attachments ❑ privately owned treatment
Treatment
works
✓❑ Section 4: Intermittent Flows
❑ w/ attachments
✓❑ Section 5: Production
❑ w/ attachments
w/ optional additional
✓❑ Section 6: Improvements
❑ w/ attachments ❑ sheets describing any
additional pollution control
tans
❑ w/ request for a waiver and ❑ w/ explanation for identical
supporting information outfalls
w/ small business exemption w/ other attachments
El ❑
d
N
0 Section 7: Effluent and Intake
❑ w/ Table A ❑ w/ Table B
Characteristics
0
❑ w/ Table C ❑ w/ Table D
d
❑ w/ Table E Elw/ analytical results as an
0
attachment
0 Section 8: Used or Manufactured
❑ w/ attachments
Toxics
0 Section 9: Biological Toxicity
❑ w/ attachments
L
Tests
U
✓❑ Section 10: Contract Analyses
❑ w/ attachments
✓❑ Section 11: Additional Information
❑ w/ attachments
HEGE[
0 Section 12: Checklist and
❑ w/ attachments
Certification Statement
12.2
Certification Statement
I certify under penalty of law that this document and all attachments were prepared under my direction or supervision in
accordance with a system designed to assure that qualified personnel properly gather and e a �"WF
submitted. Based on my inquiry of the person or persons who manage the system, or those person
responsible for gathering the information, the information submitted is, to the best of my knowledge and belief, true,
accurate, and complete. I am aware that there are significant penalties for submitting false information, including the
possibility of fine and imprisonment for knowing violations.
Name (print or type first and last name)
Official title
R. Hunter Copeland
Senior Manager, EHS
Signature
Date signed
K. �.,�--�-
z I t l "
EPA Form 3510-2C (Revised 3-19) Page 7
VED
)24
/NPDE,c

This page intentionally left blank.

EPA Ida tificabon Number NPDES Permit Number Facility Name Outfall Number Form Approved 03/05/19
NCD047373766-R2 NCO01058 Patheon Manufacturing Service 001 OMS No. 2040-0004
TABLE
A. CONVENTIONAL AND NON
CONVENTIONAL
POLLUTANTS (40 CFR
122.21(g)(7)(iii)) I
Effluent
Intake
Waiver
Unb
Optional)
Maximum
Maximum
Long -Term
Pollutant
Requested
()
Daily
Monthly
Average Daily
Number of
Long -Term
Number of
(if applicable)
Discharge
Discharge
Discharge
Analyses
Average Value
Analyses
(required)
if available
if available
❑
Check here if you have applied to your NPDES permitting authority for a waiver for all of the pollutants listed on this table for the noted outfall.
1.
Biochemical oxygen demand
❑
Concentration
Mass
(BODs)
2'
Chemical oxygen demand
❑
Concentration
Mass
(COD)
Concentration
3.
Total organic carbon (TOC)
❑
Mass
Concentration
4.
Total suspended solids (TSS)
❑
Mass
Concentration
5.
Ammonia (as N)
❑
Mass
6.
Flow
❑
Rate
Temperature (winter)
❑
°C
°C
27.8
27.8
27.8
1
NA
NA
7.
Temperature (summer)
❑
°C
°C
0
NA
NA
pH (minimum)
❑
Standard units
S.U.
6.0
7.0
NA
10
NA
NA
8.
pH (maximum)
j Standard units
S.U.
9.0
8.2
NA
30
NA
NA
I Sampling shall be conducted according to sufficiently sensitive test procedures (i.e., methods) approved under 40 CFR 136 for the analysis of pollutants or pollutant parameters or
required under 40 CFR chapter I, subchapter N or 0. See instructions and 40 CFR 122.21(e)(3).
EPA Form 351l (Revised 3-19) Page 9

This page intentionally left blank.

EPA Identification Number NPDES Permit Number Facility Name Outfall Number Form Approved 03/05/19
NCD047373766-R2 NC0010S8 Patheon Manufacturing Services 001 OMB No. 2040-0004
Presence or Absence
Intake
check one
Effluent
(optional)
Pollutant/Parameter
Testing
Units
Maximum
Maximum
Long -Tenn
Long -
(and CAS Number, if available)
Required
Believed
Believed
(specify)
Daily
Monthly
Average
Number
Tenn
Number
Present
Absent
Discharge
Discharge
Daily
of
Average
of
(required)
(rfavalable)
Discharge
Analyses
Value
Analyses
davailable
Check here if you qualify as a small business per the instructions to Form 2C and, therefore, do not need to submit quantitative data for any of the organic toxic pollutants in Sections
2 through 5 of this table. Note, however, that you must still indicate in the appropriate column of this table if you believe any of the pollutants listed are present in your discharge.
Section 1. Toxic Metals, Cyanide, and Total Phenols
1 1
Antimony, total
❑
❑
❑✓
Concentration
Mass
(7440-36-0)
1.2
Arsenic, total
❑
❑
❑✓
Concentration
Mass
(7440-38-2)
1.3
Beryllium, total
Concentration
Mass
(7440-41-7)
14
Cadmium, total
El
11
ID
Concentration
Mass
(7440-43-9)
1.5
Chromium, total
❑
❑❑
Concentration
Mass
(744047-3)
1.6
Copper, total
❑
Concentration
Mass
(7440-50-8)
1.7
Lead total
❑
El
❑
Concentration
Mass
(7439-92-1)
18
Mercury, total
❑
❑
Concentration
Mass
(7439-97-6)
19
Nickel, total
Concentration
Mass
(7440-02-0)
1.10
Selenium total
©
Concentration
Mass
(7782-49-2)
1 11
Silver, total
❑
❑
❑✓
Concentration
Mass
(7440-22-4)
1
EPA Form 3510-2C (Revised 3-19) Page 11

EPA Identification Number NPDES Permit Number Facility Name OuIIall Number Form Approved 03/05/19
NCD047373766-R2 NC001058 Patheon Manufacturing Services 001
OMB No 2040-0004
• 1
•
• 1 ••
• •• 1
Presence or Absence
Intake
check one
Effluent
(optional)
Pollutant/Parameter
Testing
Units
Maximum
Maximum
Long -Term
Long'
(and CAS Number, if available)
Required
Believed
Believed
(specify)
Daily
Monthly
Average
Number
Term
Number
Present
Absent
Discharge
Discharge
Daily
Discharge
of
Analyses
Average
AverageAnalyses
of
(required)
(rfavailable)
rf available
1.12
Thallium, total
❑
❑
El
Concentration
Mass
p440-28-0)
1.13
Zinc, total
❑
El
El
Concentration
Mass
(7440-66-6)
1.14
Cyanide, total
❑
❑
❑
Concentration
Mass
(57-12-5)
1.15
Phenols, total
❑
❑
0
Concentration
Mass
Section 2.Organic Toxic Pollutants (GC/MS Fraction —Volatile Compounds)
21
Acrolein
❑
❑
❑
Concentration
Mass
(107-02-8)
2.2
Acrylonitrile
❑
❑
❑
Concentration
Mass
(107-13-1)
2.3
Benzene
❑
❑
❑
Concentration
Mass
(71-43-2)
2.4
Bromoform
❑
❑
❑
Concentration
Mass
(75-25-2)
2.5
Carbon tetrachloride
❑
❑
❑
Concentration
Mass
(56-23-5)
2.6
Chlorobenzene
❑
❑
Concentration
Mass
(108-90-7)
2.7
Chlorodibromomethane
❑
❑
❑
Concentration
Mass
(124-48-1)
2 8
Chloroethane
El
❑
❑
Concentration
Mass
(75-00-3)
EPA Form 3510-2C (Revised 3-19) Page 12

—_7
EPA Identification Number NPDES Permit Number Facility Name Outlall Number Form Approved 03/05/19
NCD047373766-R2 NCO01058 Patheon Manufacturing Services 001 OMB No. 2040-0004
• 1
•
• • • •
• • • • 1
Presence or Absence
check one
Effluent
Intake
(optional)
Pollutant/Parameter
Testing
Units
Maximum
Maximum
Long -Term
Long -
(and CAS Number, i(available)
Required
Believed
Believed
(specify)
Daily
Monthly
Average
Number
Term
Number
Present
Absent
Discharge
Discharge
aily
of
Average
of
(required)
(if available)
Discharge a
Analyses
Analyses
(ifavailable)Value
2.9
2-chloroethylvinyl ether
Concentration
Mass
(110-75-8)
2.10
Chloroform (67-66-3)
Concentration
Mass
2.11
Dichlorobromomethane
Concentration
Mass
(75-27-4)
212
11-dichloroethane
El
11
El
Concentration
Mass
(75-34-3)
213
12-dichloroethane
❑
Concentration
Mass
(107-06-2)
214
11-dichloroethylene
a
Concentration
Mass
(75-354)
215
12-dichloropropane
Concentration
Mass
(78-87-5)
216
13-dichloropropylene
❑
❑�
Concentration
Mass
(542-75-6)
217
Ethylbenzene
Concentration
Mass
(100-41-4)
2.18
Methyl bromide
Concentration
Mass
(74-83-9)
2.119
Methyl chloride
❑✓
Concentration
Mass
(74-87-3)
2.20
Methylene chloride
Concentration
Mass
(75-09-2)
2 21
1,1,2 2- tetrachloroethane
❑❑
Concentration
Mass
(79-34-5)
1
EPA Form 3510-2C (Revised 3-19) Page 13

EPA Identification Number NPDES Permit Number Facility Name Outfall Number Form Approved 03/05/19
NCD047373766-R2 NCO01058 Patheon Manufacturing Services 001 OMB No. 2040-0004
Presence or Absence
Intake
check one
Effluent
(optional)
antlParameter
F(.nl
Testing
Units
Maximum
Maximum
Long -Term
Long•
Number, Ravailabe)
Required
Believed
Believed
(specify)
Daily
Monthly
Average
Number
Tenn
Number
Present
Absent
Discharge
Discharge
Daily
of
Average
of
(required)
(if available)
Discharge
Analyses
Value
Analyses
d avalable
2.22
Tetrachloroethylene
❑
❑
❑
Concentration
Mass
(127-18A)
2.23
Toluene
❑
❑
El
Concentration
Mass
(108-88-3)
2.24
1,2-trans-dichloroethylene
Concentration
Mass
(156-60-5)
225
1,1,1-trichloroethane
Concentration
Mass
(71-55-6)
226
1,1,2-trichloroethane
Concentration
Mass
(79-00-5)
2.27
Trichloroethylene
❑
El
✓❑
Concentration
Mass
(79-01-6)
2 28
Vinyl chloride
Concentration
Mass
(75-01 A)
Section 3. Organic Toxic Pollutants GC/MS Fraction —Acid Compounds)
31
2-chlorophenol
Concentration
Mass
(95-57-8)
3.2
2,4-dichlorophenol
Concentration
Mass
(120-83-2)
3.3
2,4-dimethylphenol
Concentration
Mass
(105-67-9)
3.4
4,6-dinitro-o-cresol
Concentration
Mass
(534-52-1)
3.5
2,4-dinitrophenol
Concentration
Mass
(51-28-5)
EPA Form 3510-2C (Revised 3-19) Page 14

EPA Identificalion Number NPDES Permd Number Facility Name Oulfall Number Form Approved 03/05/19
NCD047373766-R2 NCO01058 Patheon Manufacturing Services 001 OMB No 2040-0004
Presence or Absence
Intake
check one
Effluent
(optional)
PollutantlParameter
Testing
Units
Maximum
Maximum
Long -Term
Long-
Long -
(an, CAS Number. if available)
Required
Believed
Believed
(may)
Daily
Monthly
Average
Number
Tenn
Number
Present
Absent
Discharge
Discharge
Daily
Discharge
of
Analyses
Average
of
Analyses
(required)
(f available)
if available
Value
3.6
2-nitrophenol
❑
El
ElConcentration
Mass
(88-75-5)
3.7
4-nitrophenol
❑
❑
❑
Concentration
Mass
(100-02-7)
3.8
p-chloro-m-cresol
❑
❑
❑
Concentration
Mass
(59-50-7)
3.9
Pentachlorophenol
❑
❑
❑
Concentration
Mass
(87-86-5)
3.10
Phenol
El
11
El
Concentration
Mass
(108-95-2)
3.11
2,4,6-trichlorophenol
❑
❑
❑
Concentration
1 Mass
(88-05-2)
Section 4. Organic Toxic Pollutants GUMS Fraction —Base /Neutral Compounds)
41
Acenaphthene
❑
❑
❑
Concentration
Mass
(83-32-9)
4.2
Acenaphthylene
❑
❑
❑
Concentration
Mass
(208-96-8)
4.3
Anthracene
❑
❑
O
Concentration
Mass
(120-12-7)
4.4
Benzidine
❑
❑
❑
Concentration
Mass
(92-87-5)
4.5
Benzo (a) anthracene
❑
❑
Concentration
Mass
(56-55-3)
4.6
Benzo (a) pyrene
❑
❑
El
Concentration
Concentration
(50-32-8)
EPA Form 3510-2C (Revised 3-19) Page 15

EPA Identification Number NPDES Permit Number Facility Name Oudall Number Form Approved 03/05/19
NCD047373766-R2 NCO01058 Patheon Manufacturing Services 001 OMB No 2040-0004
Presence or Absence
Intake
check one
Effluent
(optional)
PollutantlParameter
Testing
Units
Maximum
Maximum
Long -Term
Long-
(andCASnumber,6avad be)
Required
Believed
Believed
(specify)
Daily
Monthly
Average
Number
Tenn
Number
Present
Absent
Discharge
Discharge
Daily
Discharge
of
Analyses
Average
of
Analyses
(required)
(if available)
if available
Value
4.7
3 4-benzofluoranthene
❑
❑
❑
Concentration
Mass
(205-99-2)
4.8
Benzo (ghi) perylene
❑
❑
Concentration
Mass
(191-24-2)
4.9
Benzo (k) Auoranthene
❑
ElMass
IZI
Concentration
(207-08-9)
4.10
Bis (2-chloroethoxy) methane
❑
❑
❑✓
Concentration
Mass
(111-91-1)
411
Bis (2-chloroethyl) ether
❑
❑
❑
Concentration
Mass
(111.44-4)
412
Bis (2-chloroisopropyl) ether
❑
❑
❑
Concentration
Mass
(102-80-1)
4.13
Bis (2-ethylhexyl) phthalate
❑
❑
❑
Concentration
Mass
(117-81-7)
4.14
4-bromophenyl phenyl ether
❑
❑
❑
Concentration
Mass
(101-55-3)
4.15
Butyl benzyl phthalate
❑
❑
❑
Concentration
Mass
(85-68-7)
4.16
2-chloronaphthalene
❑
❑
❑
Concentration
Mass
(91-58-7)
4.17
4-chlorophenyl phenyl ether
❑
❑
❑
Concentration
Mass
(7005-72-3)
4.18
Chrysene
Concentration
Mass
L419
Dibenzo (a,h) anthracene
❑
❑
❑
Concentration
Mass
(53-70-3)
EPA Form 3510-2C (Revised 3-19) Page 16

EPA Identification NumberES Permit Number Facility Name WWI Number Form Approved 03/05119
NPO
NCD047373766-R2 NCO01058 Patheon Manufacturing Services 001 OMB No 2040-0004
•7%mbilable)
•
• ••
• •• •1Presence
or Absence
Intake
check one
Effluent
(optional)
PoTesting
Units
Maximum
Maximum
Long•Terrn(and
Long-
Required
Believed
Believed
()
Daily
Monthly
Average
Number
m
Tenn
m
Number
Present
Absent
Discharge
Discharge
Daily
Dische
arg
ischarg
Analyses
Average
of
Analyses
(required)
(rfavailable)
(if4.20
Value
1,2-dichlorobenzene
Concentration
Mass
(95-50-1)
411
1 3-dichlorobenzene
Concentration
Mass
(541-73-1)
4.22
14-dichlorobenzene
O
Concentration
Mass
(106-46-7)
4.23
3 3-dichlorobenzidine
Concentration
Mass
(91-94-1)
4.24
Diethyl phthalate
Cl
❑
✓❑
Concentration
Mass
(84-66-2)
4,25
Dimethyl phthalate
Concentration
Mass
(131-11-3)
4,26
Di-n-butyl phthalate
O
Concentration
Mass
(84-74-2)
4.27
2,4-dinitrotoluene
❑❑
Concentration
Mass
(121-14-2)
4.28
2,6-dinitrotoluene
Concentration
Mass
(606-20-2)
429
Di-n-octyl phthalate
Concentration
Mass
(117-8")
4.30
1,2-Diphenylhydrazine
❑
❑
0
Concentration
Mass
(as azobenzene)(122-66-7)
4.31
Fluoranthene
Concentration
Mass
(206-44-0)
4.32
Fluorene
Concentration
Mass
(86-73-7)
EPA Form 3510-2C (Revised 3-19) Page 17

EPA Identification Number NPDES Permit Number Facility Name Outfall Number Form Approved 03/05/19
NCD047373766-R2 N0001058 Patheon Manufacturing Services 001 OMB No.2040-0004
Presence or Absence
Intake
check one
Effluent
(optional)
PollutantlParameter
Testing
Units
Maximum
Maximum
Long -Term
Long -
(and CAS Number, if available)
Required
Believed
Believed
(specify)
Daily
Monthly
Average
Number
Term
Number
Present
Absent
Discharge
Discharge
of
Average
of
(required)
Cif available)
DisDcharge
Analyses
Value
Analyses
ifavailable
4.33
Hexachlorobenzene
❑
❑
❑
Concentration
Mass
(118-74-1)
4.34
Hexachlorobutadiene
❑
❑
Concentration
Mass
(87-68-3)
4.35
Hexachlorocyclopentadiene
❑
❑
❑�
Concentration
Mass
(77-47-4)
4.36
Hexachloroethane
❑
❑
❑
Concentration
Mass
(67-72-1)
4.37
Indeno (1,2,3-cd) pyrene
❑
❑
Concentration
Mass
(193-39-5)
4.38
Isophorone
El
❑
Concentration
Mass
(78-59-1)
4.39
Naphthalene
❑
❑
0
Concentration
Mass
(91-20-3)
4.40
Nitrobenzene
❑
❑
Concentration
Mass
(98-95-3)
4.41
N-nitrosodimethylamine
❑
❑
Concentration
Mass
(62-75-9)
4.42
N-nitrosodi-n-propylamine
❑
❑
❑
Concentration
Mass
(621-64-7)
4.43
N-nitrosodiphenylamine
❑
❑
❑
Concentration
Mass
(86-30-6)
4.44
Phenanthrene
❑
❑
a
Concentration
Mass
(85-01-8)
4.45
Pyrene
❑
❑
Concentration
Mass
(129-00-0)
EPA Form 3510.2C (Revised 3-19) Page 18

EPA Idenfificalion Number NPDES Permit Number Facility Name OuVall Number Form Approved 03/05/19
NCD047373766-R2 NCO01058 Patheon Manufacturing Services 001 OMB No. 2040-0004
• 11M
all 1 ••
Presence or Absence
heck one
• �• 1
Units
(specify)
Effluent
Intake
(optional)
Pollutant/Parameter
(and CAS Number if available)
Testing
Required
Believed
Present
Believed
Absent
Maximum
Daily
Discharge
(required)
Maximum
Monthly
Discharge
(if available)
Long -Term
Average
Discharge chargeof
Dis
if available)Value
Number
Analyses
Long -
Tenn
Average
Number
Analyses
1 2 4-hichlorobenzene
4.46 (120-82-1)
El
El
❑
Concentration
Mass
Secdon 5. Organic Toxic Pollutants GUMS Fraction —Pesticides
5.1
Aldrin
(309-00-2)
❑
❑
Concentration
Mass
5.2
a-BHC
(319-84-6)
❑
❑
IZI
Concentration
Mass
5.3
O-BHC
(319-85-7)
El
❑
IZI
Concentration
Mass
5.4
-BHC
(58-89-9)
El
❑
El
Concentration
Mass
5.5
5-BHC
(319-86-8)
❑
❑
❑
Concentration
Mass
5.6
Chlordane
(57-74-9)
❑
ElMass
El
Concentration
5.7
4,4'-DDT
(50-29-3)
❑
❑
❑
Concentration
Mass
5.8
4 4'-DDE
(72-55-9)
❑
❑
❑
Concentration
Mass
5.9
4 4'-DDD
(72-54-8)
❑
❑
❑
Concentration
Mass
5.10
Dieldrin
(60-57-1)
❑
❑
❑
Concentration
Mass
511
a-endosulfan
(115-29-7)
❑
❑
❑
Concentration
Mass
EPA Form 3510-2C (Revised 3-19) Page 19

EPA Identification Number NPDES Permit Number Facility Name Oulfall Number Form Approved 03/05/19
NCD047373766-R2 N0001058 Patheon Manufacturing Services 001 OMB No 2040-0004
• 1
•
• 1 •'
Presence or Absence
check one
• •• 1
Units
(specify)
Effluent
Intake
(optional)
Pollutant1Parameter
(and CAS Number, rf ava table)
Testing
Required
Believed
Present
Believed
Absent
Maximum
Daily
Discharge
(required)
Maximum
MonthlyDaily
Discharge
(if available)
Long -Terre
Average
Discharge
d available)Value
Number
of
Analyses
Long -
Tenn
Average
Number
of
Analyses
512
Q-endosulfan
(115-29-7)
❑
❑
❑
Concentration
Mass
5.13
Endosulfan sulfate
(1031-07-8)
❑
❑
❑
Concentration
Mass
5.14
Endrin
(72-20-8)
❑
Concentration
Mass
5.15
Endrin aldehyde
(7421-93-4)
❑
❑
❑
Concentration
Mass
5.16
Heptachlor
(76-44-8)
❑
Concentration
Mass
5.17
Heptachlor epoxide
(1024-57-3)
❑
❑
✓❑
Concentration
Mass
5.18
PCB-1242
(53469-21-9)
❑
❑
Concentration
Mass
5.19
PCB-1254
(11097-69-1)
❑
❑
❑
Concentration
Mass
5.20
PCB-1221
(11104-28-2)
❑
❑
0
Concentration
Mass
5.21
PCB-1232
(11141-16-5)
❑
0
Concentration
Mass
5.22
PCB-1248
(12672-29-6)
❑
❑
❑
Concentration
Mass
5.23
PCB-1260
(11096-82-5)
❑
❑
❑
Concentration
Mass
5.24
PCB-1016
(12674-11-2)
❑
❑
❑
Concentration
Mass
EPA Form 3510-2C (Revised 3-19) Page 20

EPA Identification Number NPDES Permit Number Facility Name Outfall Number Form Approved 03/05/19
NCD047373766-R2 NC001058 Patheon Manufacturing Services 001 OMB No. 2040-0004
Presence or Absence
Intake
check one
Effluent
(opbonap
Pollutant/Parameter
Testing
Units
Maximum
Maximum
Long -Term
Long -
(and CAS Number, if m
Required
Believed Believed
(specify)
Daily
Monthly
a
Average
Number
Term
Number
Present Absent
Discharge
Discharge
Daily
of
Average
of
(required)
(f available)
Discharge
Analyses
Value
Analyses
if available
Toxaphene
Concentration
5.25 (8001-35-2)
El
El
Mass
r Sampling shall be conducted according to sufficiently sensitive test procedures (i.e., methods) approved under 40 CFR 136 for the analysis of pollutants or pollutant parameters or
required under 40 CFR chapter I, subchapter N or 0. See instructions and 40 CFR 122.21(e)(3).
EPA Form 3510-2C (Revised 3-19) Page 21

This page intentionally left blank.

EPA Identification Number NPUES Permit Number Facility Name Outfall Number
NCD047373766-F NCO01058 I Patheon Manufacturing Services 001
Form Approved 03/05/19
OMB No. 2040-0004
0Present
Presence or Absence
Intake
chec one
Effluent
(Optional)
Pollutant
Believed
Units
(specify)
Maximum Daily
Maximum
Monthly
Long-TermBelieved
Average Daily
Number of
Long -Term
Number of
Absent
Discharge
Discharge
Discharge
Analyses
Average
Analyses
(required)
davailable
davailable
Value
❑ Check here if you believe all pollutants on Table C to be present in your discharge from the noted outfail. You need not complete the "Presence or Absence" column of Table C for
each pollutant.
❑ Check here if you believe all pollutants on Table C to be absent in your discharge from the noted outfall. You need not complete the "Presence or Absence" column of Table C for
each pollutant.
1
Bromide
❑
❑
Concentration
Mass
(24959-67-9)
2
Chlorine, total
❑
Concentration
ug/L
1
1
1
1
NA
NA
Mass
residual
3.
Color
❑
Concentration
Mass
4.
Feral coliform
❑
0
Concentration
Mass
5
Fluoride
❑
❑
Concentration
Mass
(16984-48-8)
6
Nitrate nitrite
❑
ConcentrationMass
7.
Nitrogen, total
Concentration
Mass
organic (as N)
8.
Oil and grease
El
El
ConcentrationMass
9
Phosphorus (as
El
❑
Concentration
Mass
P), total(7723-14-0)
10
Sulfate (as SO4)
❑
❑
Concentration
Mass
(14808-79-8)
11.
Sulfide (as S)
❑
❑✓
ConcentrationMass
EPA Form 3510-2C (Revised 3-19) Page 23

EPA Identi6calion Number NPDES PemXt Nunbar Facility Name Outfall Number Form Approved 03/05/19
NCD047373766-R2 NC003058 Patheon Manufacturing Services 001 OMB No. 2040-0004
Pollutant
Presence or Absence
check one
Un is
(•p•w
Effluent
Intake
(Optional)
Believed
Present
Believed
Absent
Maximum Daily
Discharge
(required)
Maximum
Monthly
Discharge
d available)
Long -Term
Average Daily
Discharge
(if available
Number of
Analyses
Long -Term
Average
aAnalyses
Value
Number of
12
Sulfite (as S03)
(1426545-3)
❑
❑
Concentration
Mass
13.
Surfactants
❑
0
ConcentrationMass
14
Aluminum, total
(7429-90-5)
❑
❑
Concentration
Mass
15
Barium, total
(7440-39-3)
❑
❑
Concentration
Mass
16
Boron total
(7440-42-8)
❑
❑
Concentration
Mass
17.
Cobalttotal
(74404")
❑
J
❑
Concentration
Mass
18
Iron total
(7439-89-6)
❑
❑
Concentration
Mass
19
Magnesium, total
(7439-95-4)
❑
❑
Concentration
Mass
20.
Molybdenum,
total
7439-98-7
❑
Concentration
Mass
21
Manganese, total
(7439-96-5)
❑
❑
Concentration
Mass
22
Tin total
(7440-31-5)
Concentration
Mass
23
Titanium, total
(7440-32 6)
0
Concentration
Mass
EPA Fonn 3510-2C (Revised 3-19) Page 24

EPA Identification Number NPDES Permit Number Facility Name Outfall Number Form Approved 03/05/19
NCD047373766-R2 NCO01058 Patheon Manufacturing Services 001 OMB No 2040-0004
• • •
• • •
IPresence
or Absence
Intake
check one
Effluent
(Optional)
7P,
Believed
Believed
Units
(specify)
Maximum Daily
Maximum
Monthly
Long -Term
Average Daily
Number of
Long -Term
Number of
Present
Absent
Discharge
Discharge
Discharge
Analyses
Average
Analyses
(required)
if available
fl available
Value
24.
Radloactivity
Alpha, total El Concentration
Mass
Beta, total
❑
❑
Concentration
Mass
Radium, total
❑
❑�
Concentration
Mass
Radium 226, total
ConcentrationMass
Sampling shall be conducted according to sufficiently sensitive test procedures (i.e., methods) approved under 40 CFR 136 for the analysis of pollutants or pollutant parameters or
required under 40 CFR chapter I, subchapter N or 0. See instructions and 40 CFR 122.21(e)(3).
EPA Form 3510-2C (Revised 3-19) Page 25

This page intentionally left blank.

EPA Identification Number NPDES Permit Number Facility Name Outfall Number Form Approved 03/0 119
NCDO47373766-R2 NCOO1O58 Patheon Manufacturing Services 001 OMB No.2040-0004
Pollutant
Presence or Absence
check one
Reason Pollutant Believed Present in Discharge
Available Quantitative Data
(specify units)
Believed
Present
Believed
Absent
1.
Asbestos
❑
❑�
2.
Acetaldehyde
❑
❑�
3.
AIM alcohol
❑
[a
4.
AIM chloride
❑
❑�
5.
Amyl acetate
❑
❑�
6.
Aniline
❑
7.
Benzonitrile
❑
❑�
8.
Benzyl chloride
❑
✓❑
9.
Butyl acetate
❑
❑�
10.
Butylarrine
❑
❑�
11.
Captan
❑❑
12.
Carbaryl
❑
13.
Carbofuran
❑
14.
Carbon disulfide
❑
❑�
15.
Chlorpofos
❑
❑�
16.
Coumaphos
❑
❑✓
17.
Cresol
❑
❑�
18.
Crotonaldehyde
El❑✓
19.
Cyclohexane
❑
EPA Form 3510-2C (Revised 3-19) Page 27

EPA Identification Number NPDES Permit Number Facility Name Outfall Number Form Approved 03/05/19
NCD047373766-R2 NCO01058 Patheon Manufacturing Services 001 OMB No. 2040-0004
Pollutant
7
r2O.2,4-D2,4-dichlorophenoxyacetic
Presence or Absence
(check re
Reason Pollutant Believed Present in Discharge
Available Quantitative Data
(specify units)
Believed
Present
Believed
Absent
acid)
❑
❑✓
21.
Diazinon
❑
✓❑
22.
Dicamba
El
El
23.
Dichlobenil
❑❑
24.
Dichlone
❑
❑✓
25.
2,2-dichloropropionic acid
❑
26.
Dichlorvos
❑
❑�
27.
Diethyl amine
❑❑
28.
Dimethyl amine
❑
❑✓
29.
Dintrobenzene
❑
❑�
30.
Dicluat
❑
❑✓
31.
Disulfoton
❑
❑✓
32.
Diuron
❑
❑✓
33.
Epichlorohydrin
❑
✓❑
34.
Ethion
❑
0
35.
Ethylene diamine
❑
36.
Ethylene dibromide
❑
❑�
37.
Formaldehyde
❑
❑✓
38.
Furfural
❑
❑✓
EPA Form 3510-2C (Revised 3-19) Page 28

EPA Identification Number NPDES Permit Number Facility Name Oudall Number Form Approved 03/05/19
NCD047373766-R2 NCO01058 Patheon Manufacturing Services 001 OMB No. 2040-0004
Presence or Absence
Pollutant check one
Believed Believed
Present Absent
Reason Pollutant Believed Present in Discharge
Available Quantitative Data
(specify units)
39.
Guthion ❑
Isoprene ❑
❑�
40.
0
41.
Isopropanolamine
❑
0
42.
Kelthane
❑
43.
Kepone
❑
0
44.
Malathion
❑
45.
Mercaptodimethur
❑
❑✓
46.
Methoxychlor
❑
IZI
47.
Methyl mercaptan
❑
❑
48.
Methyl methacrylate
❑
0
49.
Methyl parathion
❑
50.
Mevinphos
❑❑
51.
Mexacarbate
❑
❑
52.
Monoethyl amine
❑
❑
53.
Monomethyl amine
❑
0
54.
Naled
❑
55.
Naphthenic acid
❑
❑�
56.
Nitrotoluene
❑
❑�
57.
Parathion
❑
EPA Form 3510-2C (Revised 3-19) Page 29

EPA Identificalion Number rvNuts Hermit Number Facility Name Oudall Number
NCD047373766-R2 NCO01058 I Patheon Manufacturing Services 001
Form Approved 03105/19
OMB No. 2040-0004
Pollutant
rPhe.noluffnte
I • 1Presence or Absence
check one
Available Quantitative Data
Reason Pollutant Believed Present in Discharge (specify units)
Believed
Present
Believed
Absent
❑
0
59.
Phosgene
❑
0
60.
Propargite
❑
0
61.
Propylene oxide
❑
❑✓
62.
Pyrethrins
❑
0
63.
Quinoline
❑
❑✓
64.
Resorcinol
❑
❑✓
65.
Strontium
❑
❑✓
66.
Strychnine
❑
67.
Styrene
❑
68
2,4 5-T (2,4,5-trichlorophenoxyacetic
add)
❑
0
69.
TDE (tetrachlorodiphenyl ethane)
❑
70.
2,4,5-TP [2-(2,4,5-tdchlorophenoxy)
propanoic acid
❑
71.
Trichlorofon
❑
❑r
72.
Triethanolamine
❑
0
73.
Triethylamine
❑
0
74.
Trimethylamine
❑
0
75.
Uranium
❑
0
76.
Vanadium
❑
EPA Form 351 D-2C (Revised 3-19) Page 30

EPA Identification Number NPDES Permit Number Facility Name Outfall Number Form Approved 03/05/19
NCDO47373766-R2 NCO01058 Patheon Manufacturing Services 001 OMB No. 2040-0004
Presence or Absence
check one
Reason Pollutant Believed Present in Discharge
Available Quantitative Data
(specify units)
Pollutant
Believed
Present
Believed
Absent
77. Vinyl acetate
❑
❑✓
78. Xylene
❑
❑�
79. Xylenol
❑
✓❑
80. Zirconium
❑
❑�
Sampling shall be conducted according to sufficiently sensitive test procedures (i.e., methods) approved under 40 CFR 136 for the analysis of pollutants or pollutant parameters or
required under 40 CFR chapter I, subchapter N or 0. See instructions and 40 CFR 122.21(e)(3).
EPA Form 3510-2C (Revised 3-19) Page 31

This page intentionally left blank.

PA Identification Number NPDES Pemdt Number Facility Name
NCDO47373766-R2 NCO01058 Patheon Manufacturing Services
•'•1 •1• 11 4I
TCDD Presence or
Congeners Absence
Pollutant Used or check one
Manufactured Believed Believed
Present Absent
2,3.7.8-TCDD
❑ ❑ ❑
Outfall Number
001
Results of Screening Procedure
Form Approved 03105/19
OMB No. 2040-0004
EPA Form 3510-2C (Revised 3-19) Page 33

This page intentionally left blank.

EPA Identification Number NPDES Permit Number Facility Name Outfall Number Form Approved 03/05/19
NCD047373766-R2 NC001058 Patheon Manufacturing Service 002 OMB No. 2040-0004
Effluent
Intake
Waiver
o li
Maximum
Maximum
Long -Tenn
Pollutant
Requested
Units
(s edM
Daily
Monthly
Average Daily
Number of
Long -Term
Number of
Qf applicable)
Discharge
Discharge
Discharge
Analyses
Average Value
Analyses
(required)
(if available)
davailable
❑
Check here if you have applied to your NPDES permitting authority for a waiver for all of the pollutants listed on this table for the noted outfall.
1'
Biochemical oxygen demand
❑
Concentration
Mass
(BOD5)
2'
Chemical oxygen demand
❑
Concentration
Mass
(COD)
Concentration
3.
Total organic carbon (TOC)
❑
Mass
Concentration
4.
Total suspended solids (TSS)
❑
Mass
Concentration
5.
Ammonia (as N)
❑
Mass
6.
Flow
❑
Rate
Temperature (winter)
❑
°C
°C
24.9
24.9
23.47
3
NA
NA
7.
Temperature (summer)
❑
°C
°C
31.4
31.4
29.6
3
NA
NA
pH (minimum)
❑
Standard units
S.U.
6.0
7.0
NA
10
NA
NA
8.
pH (maximum)
❑
Standard units
SM.
9.0
8.2
NA
10
NA
NA
r Sampling shall be conducted according to sufficiently sensitive test procedures (i.e., methods) approved under 40 CFR 136 for the analysis of pollutants or pollutant parameters or
required under 40 CFR chapter I, subchapter N or 0. See instructions and 40 CFR 122.21(e)(3).
EPA Form 3510-2C (Revised 3-19) Page 9

This page intentionally left blank.

EPA Identification Number NPDES Permit Number Facility Name Outfall Number Form Approved 03105/19
NCD047373766-R2 NCO01058 Patheon Manufacturing Services 002 OMB No. 2040-0004
Presence or Absence
Intake
7(aMCAS
checb one
Effluent
(optional)
ntlParameter
Testing
Units
Maximum
Maximum
Long -Term
Long -
umber. it available)
Required
Believed
Believed
(specify)
Daily
Monthly
Average
Number
Term
Number
Present
Absent
Discharge
Discharge
Daily
of
Average
of
(required)
(if available)
Discharge
Analyses
Value
Analyses
if available
❑ Check here if you qualify as a small business per the instructions to Form 2C and, therefore, do not need to submit quantitative data for any of the organic toxic pollutants in Sections
2 through 5 of this table. Note, however, that you must still indicate in the appropriate column of this table if you believe any of the pollutants listed are present in your discharge.
Seddon 1. Toxic Metals, Cyanide, and Total Phenols
1 1
Antimony, total
❑
❑
❑
Concentration
Mass
(7440-36-0)
1.2
Arsenic, total
❑
❑
❑✓
Concentration
Mass
(7440-38-2)
1.3
Beryllium, total
❑
❑
✓❑
Concentration
Mass
(744041-7)
1.4
Cadmium, total
❑
❑
IZI
Concentration
Mass
(7440.43-9)
1.5
Chromium, total
❑
❑
❑
Concentration
Mass
(7440-47-3)
1.6
Copper, total
❑
❑
❑
Concentration
Mass
(7440-50-8)
1.7
Lead total
❑
❑
❑
Concentration
Mass
(7439-92-1)
1.8
Mercury, total
❑
❑
❑
Concentration
Mass
(7439-97-6)
1.9
Nickel total
❑
❑❑
Concentration
Mass
(7440-02-0)
1.10
Selenium total
❑
❑
❑
Concentration
Mass
(778249-2)
1.11
Silver, total
❑
❑
❑
Concentration
Mass
(7440-224)
1
EPA Form 3510-2C (Revised 3-19) Page 11

EPA Identification Number NPDES Permit Number Facility Name WWI Number Form Approved 03/05/19
NCDO47373766-R2 N00010S8 Patheon Manufacturing Services 002 OMB No 2040-0004
Presence or Absence
check one
Units
(specify)
Effluent
Intake
(optional)
Pollutant/Parameter
(and CAS Number,'rf available)
Testing
Required
Believed
Present
Believed
Absent
Maximum
Daily
Discharge
(required)
Maximum
Monthly
Discharge
(d available)
Long -Term
Average
Daily
Discharge
rf available
Number
°f
Analyses
Long -
Term
Average
Value
Number
of
Analyses
1.12
Thallium total
(7440-28-0)
❑
❑
❑�
Concentration
Mass
1.13
Zinc total
(7440-66-6)
❑
❑
O
Concentration
Mass
1.14
Cyanide, total
(57-12-5)
❑
❑
Concentration
Mass
1.15
Phenols, total
❑
❑❑
Concentration
Mass
Section 2.Organic Toxic Pollutants (GC/MS Fraction —Volatile Compounds)
21
Acrolein
(107-02-8)
❑
❑
❑
Concentration
Mass
2.2
Acrylonitrile
(107-13-1)
❑
❑
El
Concentration
Mass
2.3
Benzene
(71.43-2)
❑
❑
0
Concentration
Mass
2.4
Bromofomt
(75-25-2)
❑
❑
❑�
Concentration
Mass
2.5
Carbon tetrachloride
(56-23-5)
❑
❑
Concentration
Mass
2.6
Chlorobenzene
(108-90-7)
El
ElMass
Concentration
2.7
Chlorodibromomethane
(124-48-1)
El
❑
Concentration
Mass
2.8
Chloroethane
(75-00-3)
ElMass
Concentration
EPA Form 3510-2C (Revised 3-19) Page 12

EPA Identification Number NPDES Permit Number Facility Name Outrall Number Form Approved 03/05/19
NCD047373766-R2 NC001058 Patheon Manufacturing Services 002 OMB No.2040-0004
•
•
•
• 1 ••ILION•
Presence or Absence
'• 1
Intake
chec one
Effluent
(optional)
PollutantlParameter
Testing
Units
Maximum
Maximum
Long -Term
Long*
(and CAS Nr•rber, if available)
Required
Believed
Believed
(specify)
Daily
Monthly
Average
Number
Term
Number
Present
Absent
Discharge
Discharge
Daily
Discharge
of
Analyses
Average
of
Analyses
(required)
(if available)
d available
Value
2.9
2-chloroethylvinyl ether
❑
❑
❑
Concentration
Mass
(110-75-8)
2.10
Chloroform (67-66 3)
❑
❑
Concentration
Mass
211
Dichlorobromomethane
❑
❑
❑
Concentration
Mass
(75-27-4)
2.12
1,1-dichloroethane
El
❑
ID
Concentration
Mass
(75-34-3)
2.13
1,2-dichloroethane
❑
ElMass
Concentration
(107-06-2)
214
1,1-dichloroethylene
❑
❑
❑
Concentration
Mass
(75-354)
215
1,2-dichloropropane
❑
❑
❑
Concentration
Mass
(78-87-5)
216
1,3-dichloropropylene
❑
❑
❑
Concentration
Mass
(542-75-6)
217
Ethylbenzene
❑
❑
❑
Concentration
Mass
(10041-4)
218
Methyl bromide
❑
❑
❑
Concentration
Mass
(74-83-9)
2.19
Methyl chloride
❑
❑
❑
Concentration
Mass
(74-87-3)
2.20
Methylene chloride
❑
❑
❑
Concentration
Mass
(75-09-2)
221
1,1,2,2-tetrachloroethane
❑
❑
❑
Concentration
Imass
(79-34-5)
1
EPA Form 3510-2C (Revised 3-19) Page 13

EPA Identification Number NPDES Permit Number Facility Name Ouffall Number Form Approved 03/05/19
NCD047373766-R2 NCO01058 Patheon Manufacturing Services 002 OMB No.2040-0004
TABLE
B. TOXIC METALS, CYANIDE,
TOTAL PHENOLS,
AND ORGANIC TOXIC
POLLUTANTS (40 CFR
122.21(g)(7)(v))'
Presence or Absence
Intake
check one
Effluent
(optional)
Pollutant/Parameter
Testing
Units
Maximum
Maximum
Long -Term
Long -
(and CAS Number, rf available)
Required
Believed
Believed
(specify)
Daily
Monthly
Average
Number
Term
Number
Present
Absent
Discharge
Discharge
Daily
of
Average
of
(required)
(if available)
Discharge
Analyses
Value
Analyses
d available
2.22
Tetrachloroethylene
❑
❑
❑
Concentration
Mass
(127-18-4)
2.23
Toluene
❑
❑
a
Concentration
Mass
(108-88-3)
224
1,2-trans-dichloroethylene
❑
❑
❑✓
Concentration
Mass
(156-60-5)
225
11,1-hichloroethane
❑
❑
❑
Concentration
Mass
(71-55-6)
2.26
1 1,2-trichloroethane
❑
❑
❑
Concentration
Mass
(79-00-5)
2.27
Trichloroethylene
❑
❑
❑✓
Concentration
Mass
(79-01-6)
2.28
Vinyl chloride
❑
❑
❑
Concentration
Mass
(75-01-4)
Section 3. Organic Toxic Pollutants GC/MS Fraction —Acid Compounds
31
2-chlorophenol
❑
❑
✓❑
Concentration
Mass
(95-57-8)
3.2
2 4-dichlorophenol
❑
❑
El
Concentration
Mass
(120-83-2)
3.3
2 4-dimethylphenol
❑
❑
IZI
Concentration
Mass
(105-67-9)
3.4
4 6-dinitro-o-cresol
❑
❑
❑
Concentration
Mass
(534-52-1)
3.5
2 4-dinitrophenol
❑
❑
Concentration
Mass
(51-28-5)
EPA Form 3510-2C (Revised 3-19) Page 14

EPA Identification Number NPDES Permit Number Facility Name Ourfall Number Form Approved 03/05/19
NCD047373766-R2 NCO01058 Patheon Manufacturing Services 002 OMB No,2040-0004
Presence or Absence
Intake
check one
Effluent
(optional)
nt/Parameter
F(.npl'CAS
Testing
Units
Maximum
Maximum
Long -Term
Long-
umber,'rf available)
Required
Believed
Believed
(specify)
Daily
Monthly
Average
Number
Term
Number
Present
Absent
Discharge
Discharge
Daily
Discharge
of
Analyses
Average
of
Analyses
(squired)
(rfavailable)
davailable
Value
3.6
2-nitrophenol
❑
❑
Concentration
Mass
(88-75-5)
3.7
4-nitrophenol
El
❑
IZI
Concentration
Mass
(100-02-7)
3.8
p-chloro-m-cresol
❑
ElMass
El
Concentration
(59-50-7)
3.9
Pentachlorophenol
El
ElMass
El
Concentration
(87-86-5)
3.10
Phenol
El
ElMass
El
Concentration
(108-95-2)
3.11
2,4,6-trichlorophenol
El
El
El
Concentration
Mass
(88-05-2)
Section 4. Organic Toxic Pollutants(GC/MS Fraction —Base /Neutral Compounds
41
Acenaphthene
❑
❑
❑
Concentration
Mass
(83-32-9)
4.2
Acenaphthylene
❑
❑
❑
Concentration
Mass
(208-96-8)
4.3
Anthracene
❑
❑
Concentration
Mass
(120-12-7)
4.4
Benzidine
❑
❑
Concentration
Mass
(92-87-5)
4.5
Benzo (a) anthracene
Concentration
Mass
(56-55-3)
4.6
Benzo (a) pyrene
❑
❑
❑
Concentration
Mass
(50-32-8)
EPA Form 3510-2C (Revised 3-19) Page 15

EPA Identification Number NPDES Permit Number Facility Name Outfall Number Form Approved 03/05/19
NCD047373766-R2 NCO01058 Patheon Manufacturing Services 002 OMB No. 2040-0004
Presence or Absence
Intake
check one
Effluent
(optional)
Pollutant/Parameter
'rfavailable)
Testing
Units
Maximum
Maximum
Long -Term
Long"
(and CAS Number,
Required
Believed
Believed
(specify)
Daily
Monthly
Average
Number
Term
Number
Present
Absent
Discharge
Discharge
Daily
of
Average
of
(required)
(if available)
Discharge
Analyses
Value
Analyses
davailable
4.7
3 4-benzofluoranthene
❑
❑
Concentration
Mass
(205-99-2)
4.8
Benzo (ghi) perylene
❑
❑
❑
Concentration
Mass
(191-24-2)
4.9
Benzo (k) fluoranthene
❑
❑
❑
Concentration
Mass
(207-08-9)
4.10
Bis (2-chloroethoxy) methane
❑
❑
❑
Concentration
Mass
(111-91-1)
411
Bis (2-chloroethyl) ether
❑
❑
❑✓
Concentration
Mass
(111-44-4)
412
Bis (2-chloroisopropyl) ether
❑
❑
❑✓
Concentration
Mass
(102-80-1)
4.13
Bis (2-ethylhexyl) phthalate
❑
❑
❑✓
Concentration
Mass
(117-81-7)
4.14
4-bromophenyl phenyl ether
❑
❑
❑✓
Concentration
Mass
(101-55-3)
4.15
Butyl benzyl phthalate
❑
❑
❑
Concentration
Mass
(85-68-7)
4.16
2-chloronaphthalene
❑
❑
❑
Concentration
Mass
(91-58-7)
a.17
4-chlorophenyl phenyl ether
❑
❑
❑
Concentration
Mass
(7005-72-3)
418
Chrysene
❑
❑
❑
Concentration
Mass
(218-01-9)
4.19
Dibenzo (a,h) anthracene
❑
❑
El
Concentration
Mass
(53-70-3)
EPA Form 3510-2C (Revised 3-19) Page 16

EPA Identification Number NPDES Permit Number Facility Name Outfall Number Form Approved 03/05/19
NCD047373766-P2 NCOO1OS8 Patheon Manufacturing Services 002 OMB No. 2040-0004
Presence or Absence
Intake
check one
Effluent
(optional)
Pollutant/Parameter
Testing
Units
Maximum
Maximum
Long -Term
Long-
(and CAS Number, if available)
Required
Believed
Believed
(specify)
Daily
Monthly
Average
Number
Term
Number
Present
Absent
Discharge
Discharge
Daily
Discharge
of
Analyses
Average
of
Analyses
(required)
(davalable)
davailable
Value
4.20
12-dichlorobenzene
Concentration
Mass
(95-50-1)
4.21
1 3-dichlorobenzene
❑
❑❑
Concentration
Mass
(541-73-1)
4.22
14-dichlorobenzene
❑
El
✓❑
Concentration
Mass
(106A6-7)
4.23
3,3-dichlorobenzidine
Concentration
Mass
(91-94-1)
4.24
Diethyl phthalate
El
©
Concentration
Mass
(84-66-2)
4.25
Dimethyl phthalate
©
Concentration
Mass
(131-11-3)
4.26
Di-n-butyl phthalate
❑
❑
©
Concentration
Mass
(84-74-2)
4.27
2 4-dinitrotoluene
©
Concentration
Mass
(121-14-2)
4.28
2 6-dinitrotoluene
Concentration
Mass
(606-20-2)
4.29
Di-n-octyl phthalate
❑
11
a
Concentration
Mass
(117-84-0)
4.30
1,2-Diphenylhydrazine
❑
❑
0
Concentration
Mass
(as azobenzene)(122-66-7)
4.31
Fluoranthene
El
El
ID
Concentration
Mass
(206-44-0)
4.32
Fluorene
❑
❑
El
Concentration
(86-73-7)
1
1Mass
EPA Form 3510-2C (Revised 3-19) Page 17

EPA Identification Number NPDES Permit Number Facility Name Outfall Number Form Approved 03/05119
NCD047373766-R2 N0001058 Patheon Manufacturing Services 002 OMB No, 2040-0004
Presence or Absence
Intake
check one
Effluent
(optional)
Pollutant/Parametar
Testing
Units
Maximum
Maximum
Long -Term
Long -
(and CAS Number, davaWable)
Required
Believed
Believed
(specify)
Daily
Monthly
Average
Number
Term
Number
Present
Absent
Discharge
Discharge
Daily
Discharge
of
Analyses
Average
of
Analyses
(required)
(if available)
if available
Value
4.33 Hexachlorobenzene
El
❑
❑
Concentration
Mass
(118-74-1)
4.34 Hexachlorobutadiene
❑
❑
❑
Concentration
Mass
(87-68-3)
4.35 Hexachlorocyclopentadiene
❑
❑
❑
Concentration
Mass
(77-47-4)
4.36 Hexachloroethane
❑
❑
❑✓
Concentration
Mass
(67-72-1)
4.37
Indeno (1,2,3-cd) pyrene
❑
❑
❑
Concentration
Mass
(193-39-5)
4.38 Isophorone
❑
❑
❑
Concentration
Mass
(78-59-1)
Naphthalene
4.39
❑
❑
Concentration
Mass
(91-20-3)
Nitrobenzene
4.40
❑
❑
Concentration
Mass
(98-95.3)
4.41 N-nitrosodimethylamine
❑
El
❑✓
Concentration
Mass
(62-75-9)
4.42 N-nitrosodi-n-propylamine
❑
❑
Concentration
Mass
(621-64-7)
4.43 N-nitrosodiphenylamine
❑
❑
❑
Concentration
Mass
(86-30-6)
4.44
Phenanthrene
El
Concentration
Concentration
(85-01-8)
Pyrene
4.45
❑1
El
El
Concentration
1Mass
(129-00-0)
EPA Form 3510-2C (Revised 3-19) Page 18

EPA Identification Number NPDES Permit Number Facility Name Outlall Number Form Approved 03/05/19
NCD047373766-R2 NC001058 Patheon Manufacturing Services 002 OMB No. 2040-0004
• •
•
•
Presence or Absence
check one
Units
(specify)
Effluent
Intake
(option)
Pollutant/Parameter
(and CAS Number, rfavailable)
Testing
Required
Believed
Present
Believed
Absent
Maximum
Daily
Discharge
Maximum
Monthly
Discharge
e)
Long -Term
Average
Daily
Discharge
rf available
Number
of
Analyses
Long -
Term
Average
alue
Number
of
Analyses
1 2 4-trichlorobenzene
4.46 (120-82-1)
❑
El
El
Concentration
Mass
Section 5. Organic Toxic Pollutants (GCIMS Fraction —Pesticides
5.1
Alddn
(309-00-2)
❑
❑
Concentration
Mass
5.2
a-BHC
(319-84-6)
❑
❑
Concentration
Mass
5.3
(i-BHC
(319-85-7)
El
ElMass
El
Concentration
5.4
V-BHC
(58-89-9)
❑
❑
❑
Concentration
Mass
5.5
bBHC
(319-86-8)
El
❑
IZI
Concentration
Mass
5.6
Chlordane
(57-74-9)
❑
❑
❑
Concentration
Mass
5.7
4,4'-DDT
(50-29-3)
❑
❑
❑
Concentration
Mass
5.8
4 4'-DDE
(72-55-9)
❑
❑
❑
Concentration
Mass
5.9
4 4'-DDD
(72-54-8)
❑
❑
❑
Concentration
Mass
5.10
Dieldrin
(60-57-1)
❑
❑
Concentration
Mass
511
a-endosulfan
(115-29-7)
❑
❑
❑
Concentration
Mass
EPA Form 3510-2C (Revised 3-19) Page 19

EPA Identification Number NPDES Permit Number Facility Name Outfall Number Form Approved 03/05/19
NCD047373766-R2 NC001058 Patheon Manufacturing Services 002 OMB No. 2040-0004
Pollutant/Parameter
(and CAS Number.. if available)
Testing
Required
Presence or Absence
check one
Units
(specify)
Effluent
Intake
(optional)
Believed
Present
Believed
Absent
Maximum
Daily
Discharge
(required)
Maximum
Monthly
Discharge
Qfavailable)
Long -Term
Average
Daily
Discharge
if available
Number
of
Analyses
Long -
Tenn
Average
Value
Number
of
Analyses
5.12
endosulfan
(115-29-7)
Concentration
Mass
5.13
Endosulfan sulfate
(1031-07-8)
Concentration
_-
Mass
5.14
Endrin
(72-20-8)
Concentration
Mass
5.15
Endrin aldehyde
(7421-93-4)
Concentration
Mass
5.16
Heptachlor
(76-44 8)
Concentration
Mass
5.17
Heptachlor epoxide
(1024-57-3)
Concentration
Mass
5.18
PCB-1242
(53469-21-9)
❑
❑
I El
Concentration
Mass
5.19
PCB-1254
(11097-69-1)
IZI
Concentration
Mass
5.20
PCB-1221
(11104-28-2)
❑
Concentration
Mass
5.21
PCB-1232
(11141-16-5)
El
Concentration
Mass
5.22
PCB-1248
(12672-29-6)
Concentration
Mass
5.23
PCB-1260
(1109&82-5)
Concentration
Mass
5.24
PCB-1016
(12674-11-2)
El
Concentration
Mass
EPA Form 3510.2C (Revised 3-19) Page 20

EPA Idenfificabon Number NPDES Permit Number Facility Name Outfall Number Form Approved 03/05/19
NCDo47373766-R2 NCO01058 Patheon Manufacturing Services 002 OMB No 2040-0004
Presence or Absence
Intake
check one
Effluent
(Intake
ter
Testing
Units
Maximum
Maximum
Long -Term
Long-
CASavailable)
IT7
Required
Believed
Believed
(specify)
Daily
Monthly
Average
Number
Term
Number
Present
Absent
Discharge
Discharge
Daily
of
Average
of
(required)
(if available)
Discharge
Analyses
Value
Analyses
rf available
Concentration
❑
—
Mass
' Sampling shall be conducted according to sufficiently sensitive test procedures (i.e., methods) approved under 40 CFR 136 for the analysis of pollutants or pollutant parameters or
required under 40 CFR chapter I, subchapter N or 0. See instructions and 40 CFR 122.21(e)(3).
EPA Form 3510-2C (Revised 3-19) Page 21

This page intentionally left blank.

EPA Identification NumberES Permit Number Facility Name Outfall Number Form Approved 03/05/19
NPD
NCDO47373766-R2 NCOO1O58 Patheon Manufacturing Services 002 OMB No. 2040-0004
Intake
Presence or Absence
check one
Effluent
(Optional)
Pollutant
Believed
Believed
Units
(specify)
Maximum Dail y
Maximum
Monthly
Long-Term
Average Daily
Number of
Long -Term
Number of
Present
Absent
Discharge
Discharge
Discharge
Analyses
Average
Analyses
(required)
(if available)
if available
Value
❑ Check here if you believe all pollutants on Table C to be present in your discharge from the noted outfall. You need not complete the "Presence or Absence' column of Table C for
each pollutant.
❑ Check here if you believe all pollutants on Table C to be absent in your discharge from the noted outfall. You need not complete the "Presence or Absence" column of Table C for
each pollutant.
Bromide
❑
❑
Concentration
Mass
(24959-67-9)
2
Chlorine, total
❑
Concentration
ug/L
29
29
11.2
10
NA
NA
Mass
residual
3.
Color
❑
❑✓
Concentration
Mass
4.
Fecal coliform
❑
❑✓
ConcentrationMass
5
Fluoride
❑
❑
Concentration
Mass
(16964-48-8)
6
Nitrate nitrite
❑
0ConcentrationMass
T'
Nitrogen, total
❑
✓
❑
Concentration
Mass
organic (as N)
8.
Oil and grease
❑
❑✓
ConcentrationMass
9
Phosphorus (as
❑
Concentration
Mass
P), total (7723-14-0)
1l1
Sulfate (as SO4)
❑
✓
❑
Concentration
Mass
(14606-79-6)
11.
Sulfide (as S)
❑
❑✓
Concentration
Mass
EPA Form 3510-2C (Revised 3-19) Page 23

EPA Identification Number NPDES Permit Number Facility Name Outfall Number Form Approved 03/05/19
NCD047373766-R2 N0001058 Patheon Manufacturing Services 002 OMB No. 2040-0004
Pollutant
Presence or Absence
check one
Units
(specify)
Effluent
Intake
(Optional)
Believed
Present
Believed
Absent
Maximum Daily
Discharge
(required)
Maximum
Monthly
Discharge
rfavailable
Long•Term
Average Daily
Discharge
[if available)
Number of
Analyses
Long•7ertn
Average
Value
Number of
Analyses
12
Sulfite (as S03)
(14265-45-3)
❑
❑
Concentration
Mass
13.
Surfactants
El
Concentration
Mass
14
Aluminum, total
(7429-90-5)
❑
❑
Concentration
Mass
15
Barium, total
(7440-39-3)
❑
❑✓
Concentration
Mass
16
Boron total
(7440.42-8)
❑
❑
Concentration
Mass
17.
Cobalt total
(7440484)
❑
❑
Concentration
Mass
18
Iron total
(7439-89-6)
❑
❑
Concentration
Mass
19
Magnesium, total
(7439-95-4)
❑
❑
Concentration
Mass
20.
Molybdenum,
total
7439-98-7
❑
Concentration
Mass
21
Manganese, total
(7439-96-5)
❑
❑
Concentration
Mass
22
Tin total
(7440.31-5)
❑�
Concentration
Mass
23
Titanium, total
(7440-32-6)
❑
❑
Concentration
Mass
EPA Form 351D-2C (Revised 3-19) Page 24

EPA Identification Number NPDES Permit Number Facility Name Outfall Number Form Approved 03/05/19
NCDO47373766-R2 NC0O1058 Patheon Manufacturing Services 002 OMB No 2040-0004
MOrlign
Presence or Absence
Intake
check one
Effluent
(Optional)
Pollutant
Believed
Believed
Una
(specify)
Maximum Dail y
Maximum
Monthly
Long -Term
Average Daily
Number of
Long -Terre
Number of
Present
Absent
Discharge
Discharge
Discharge
Analyses
Average
Analyses
(required)
d available
d available
value
24.
Radioactivity
Alpha, total
❑
❑�
Concentration
Mass
Beta, total
❑
0
Concentration
Mass
Radium, total
❑
0
Concentration
Mass
Radium 226, total
❑
0
Concentration
Mass
r Sampling shall be conducted according to sufficiently sensitive test procedures (i.e., methods) approved under 40 CFR 136 for the analysis of pollutants or pollutant parameters or
required under 40 CFR chapter I, subchapter N or 0. See instructions and 40 CFR 122.21(e)(3).
EPA Form 3510-2C (Revised 3-19) Page 25

This page intentionally left blank.

EPA Identification Number NPDES Permit Number Facility Name Outfall Number Form Approved 03105119
NCDO47373766-R2 NC001058 Patheon Manufacturing Services 002 OMB No 2040-0004
Pollutant
rAsbetos
1 • •Presence or Absence
check one
Available Quantitative Data
Reason Pollutant Believed Present in Discharge (specify units)
Believed
Present
Believed
Absent
❑
2.
Acetaldehyde
❑
❑✓
3.
AIM alcohol
❑
❑
4.
Allyl chloride
❑❑
5.
Amyl acetate
❑❑
6.
Aniline
❑
0
7.
Benzonitrile
❑
8.
Benzyl chloride
❑
❑�
9.
Butyl acetate
❑
❑�
10.
BuMamine
❑
❑�
11.
Caplan
❑
0
12.
Carbaryl
❑
❑�
13.
Carbofuran
❑
0
14.
Carbon disulfide
❑
❑�
15.
Chlorpyrifos
❑
16.
Coumaphos
❑
❑�
17.
Cresol
❑
❑�
18.
Crotonaldehyde
❑
❑�
19.
Cydohexane
❑
EPA Fonn 3510.2C (Revised 3-19) Page 27

EPA Identification Number NPDES Permit Number Facility Name Oudall Number Form Approved 03/05/19
NCD047373766-R2 NCO01058 Patheon Manufacturing Services 002 OMB No. 2040-0004
i
'11•
Pollutant
-[list
Presence or Absence
check one
Reason Pollutant Believed Present in Discharge
— — -
Available Quantitative Data
(specify units)
—
Believed
Present
Believed
Absent
20. 2,4-D (2,4-dichlorophenoxyacetic acid)
❑
❑�
—
21. Diazinon
❑❑
22. Dicamba
❑
❑�
23. Dichlobenil
❑
❑�
24. Dichlone
❑
❑�
25. 2,2-dichloropropionic acid
❑
❑�
26. Dichlorvos
❑❑
27. Diethyl amine
❑
❑✓
28. Dimethyl amine
❑
❑�
29. Dintrobenzene
❑
❑✓
30. Diquat
El
El
31. Disulfoton
❑
❑�
32. Diuron
❑❑
33. Epichlorohydhn
❑
0
34. Ethion
❑
❑�
35. Ethylene diamine
❑
❑✓
36. Ethylene dibromide
❑
❑�
37. Formaldehyde
❑
❑✓
38. Furfural
❑
m
EPA Form 3510-2C (Revised 3-19) Page 28

EPA Identification Number NPDES Permit Number Facility Name Outfall Number Form Approved 03105/19
NCD047373766-R2 NCO01058 Patheon Manufacturing Services 002 OMB No 2040-0004
Pollutant
rGuthion
Presence or Absence
check one
Reason Pollutant Believed Present in Discharge
Available Quantitative Data
(specify units)
— — —
Believed
Present
Believed
Absent
❑
❑
— — — — — —
-
40. Isoprene
❑
0
41. Isopropanolamine
❑
❑�
42. Kelthane
❑
IZI
43. Kepone
❑
44. Marathion
❑
❑�
45. Mercaptodimethur
❑
❑�
46. Methoxychlor
❑
❑�
47.
Methyl mercaptan
❑
❑�
48.
Methyl methacrylate
❑
❑✓
49.
Methyl parathion
❑
0
50. Mevinphos
❑
❑✓
51. Mexacarbate
❑
❑�
52. Monoethyl amine
❑
53. Monomethyl amine
❑
❑�
54. Naled
❑
❑�
55. Naphthenic acid
❑
❑�
56.
Nitrotoluene
❑
0
57.
Parathion
❑
❑�
EPA Form 3510-20 (Revised 3-19) Page 29

EPA Identificafion Number NPDES Permit Number Facility Name Outfall Number Form Approved 03/05/19
NCD047373766-R2 NCO01058 Patheon Manufacturing Services 002 OMB No 2040-0004
1 '11
Pollutant
1 � •I
Presence or Absence
check one
Reason Pollutant Believed Present in Discharge
Available Quantitative Data
(specify units)
Believed
Present
Believed
Absent
58.
Phenolsulfonate
❑
- - ---
59.
Phosgene
❑
❑�
60.
Propargite
❑
❑�
61.
Propylene oxide
❑
❑�
62.
Pyrethrins
❑
❑�
63.
Quinoline
❑❑
64.
Resorcinol
❑
65.
Strontium
❑
❑✓
66.
Strychnine
❑
67.
Styrene
❑
❑✓
68.
2,4 5-T (2,4,5-trichlorophenoxyacetic
acid
❑
69.
TDE (tetrachlorodiphenyl ethane)
❑
❑✓
70.
2,4,5-TP [2-(2,4,5-trichlorophenoxy)
ro anoic acid
❑
71.
Trichlorofon
❑
72.
Triethanolamine
❑❑
73.
Triethylamine
❑
74.
Trimethylamine
❑
ID
75.
Uranium
❑
❑�
76.
Vanadium
❑
❑�
EPA Form 3510.21C (Revised 3-19) Page 30

EPA Identification Number NPDES Permit Number Facility Name Outfall Number Form Approved 03/05/19
NCDO47373766-R2 NCOO1O58 Patheon Manufacturing Services 002 OMB No. 2040-0004
Pollutant(check
rVnyl
Presence or Absence
°ne
Reason Pollutant Believed Present in Discharge
Available Quantitative Data
(specify-ts)
Believed
Present
Believed
Absent
❑
78.
Xylene
❑
79.
Xylenol
❑
80.
Zirconium
❑
❑✓
I Sampling shall be conducted according to sufficiently sensitive test procedures (i.e., methods) approved under 40 CFR 136 for the analysis of pollutants or pollutant parameters or
required under 40 CFR chapter I, subchapter Nor 0. See instructions and 40 CFR 122.21(e)(3).
EPA Form 3510-2C (Revised 3-19) Page 31

This page intentionally left blank.

EPA Identification Number
NCD047373766-R2
Pollutant
2,3.7.8-TCDD
NCO01058
TCDD Presence or
Congeners Absence
Patheon Manufacturing Services
Used or I
Believed I Believed
Manufactured Present I Absent
❑ ❑ 1 R
002
Results of Screening Procedure
Form Approved 03/05119
OMB No, 2040-0004
EPA Form 3510-2C (Revised 3-19) Page 33

PROCESS FLOW
Makeup
1,800 gpd
average
9,300 gpd
average
Makeup
XXXX gpd
average
Cooling Tower Cooling Tower
Main Tower 2 Main Tower 3
Blowdown ! r! Blowdown
ischarge to
ity Option
2,210 gpd Dechlorination
average
Discharge 002
Stormwater
Option
O utfa 11001
Stormwater
Option
970 gpd average
2910 gpd
average

BIOCIDE/CHEMICAL TREATMENT
WORKSHEET-FORM 101
The following calculations are to be performed on any biocidal products ultimately discharged to the surface waters of
North Carolina. This worksheet must be completed separately for each biocidal product in use. This worksheet is to be
returned with all appropriate data entered into the designated areas with calculations performed as indicated.
I. Facility Name: Patheon Manufacturing Services LLC
NPDES # NC: 0001058
Outfall #: 001 & 002
County: Pitt
Receiving Stream: Parker's Creek 7Q10: 0.38 (cfs)
(All above information supplied by the Division of Water Quality)
What is the Average Daily Discharge (A.D.D.) volume of the water handling systems to the receiving water body?
A.D.D. _ .0185 (in M.G.D.)
Please calculate the Instream Waste Concentration (IWC in percent) of this discharge using the data entered
above.
(A.D.D.) X 100 _ ( ) X 100
(7Q10)(0.646) + (A.D.D) - ( )(0.646) + ( )=0.02553 IWC =
This value (IWC) represents the waste concentration to the receiving stream during low flow conditions.
II. What is the name of the whole product chemical treatment proposed for use in the discharge identified in Part I?
12.5 % Sodium hypochlorite
Please list the active inaredients and percent composition:
Active
Function
Wt. %
Sodium hypochlorite
Biocide
12.5
What feed or dosage rate (D.R.) is used in this application? The units must be converted to maximum grams
of whole product used in a 24hr period.
D.R.= 4,255 grams/24hr period
Please note, fluid ounces (a volume) must be converted to grams (a mass). The formula for this conversion is:
Grams of product = fluid oz. of product X 1 gal. water X 8.34 lbs. X specific gravity of product X 453.59g.
128 fl. oz. 1 gal. water 1 lb.

Facility Name: DSM Pharmaceuticals, Inc
NPDES #: NC00010
Estimate total volume of the water handling system between entry of biocidal product and NPDES discharge
point. On an attached sheet please provide justification for this estimate (system volume, average cycles per
blowdown, holding lagoon size, etc.)
Volume= 0.
million gallons
What is the pH of the handling system prior to biocide addition? If unknown, enter N/A
What is the decay rate (D.K.) of the product? If unknown, assume no decay (D.K.=O) and proceed to asterisk.
The degradation must be stated at pH level within 1/2 pH standard unit within handling system. Enter the half life
(Half Life is the time required for the initial product to degrade to half of its original concentration). Please
provide copies of the sources of this data.
H.L. = 0.00034 Days
The decay rate is equal to - L. X 0.69 = 0' =Decay Rate (D.K.)
H.
Calculate degradation factor (D.F.). This is the first order loss coefficient.
D.F. _ (Volume)
Calculate
Dischg Conc. _ (D.F.)(Volume)(3785) _ ( )( ))(3785) = 0.61 mg/I
Calculate concentration of biocide instream during low flow conditions.
(Receiving Stream Concentration)
(Dischg. Conc.) x (IWC%) ( ) x 100 100 000155 mg/I
= -
Receiving Stream Concentration
III. Calculate regulated limitation.
List all LC50 and EC50 data available for the whole product according to the following columns. (Note that units
should be in mg/1). See SDS
D.W.Q. Form 101 (612000) 2

Facility Name: DSM Pharmaceuticals, Inc
NPDES #: NC000105
Choose the lowest LC50/EC50 listed above:
Enter the LC50/EC50: 0.25
If the half life (H.L.) is less than 4 days, perform the following calculation.
Regulated Limitation = 0.05 x LC50 = .0125 mg/I
If the half life (H.L.) is greater than or equal to 4 days or unknown, perform the following calculation.
Regulated Limitation = 0.01 x LC50 = mg/I
Choose the appropriate regulated limitation from the calculations immediately above and place in this blank:
0.0125 mg/liter
From Part II enter the receiving stream concentration:
0.000155 mg/liter
IV. Analysis.
If the receiving stream concentration is greater than the calculated regulated limitation, then this biocide is
unacceptable for use.
Person in Responsible Charge
Name (Print)
Signature Date
Person Completing This Worksheet (If different from above)
Name (Print)
Signature Date
Please submit to: Division of Water Quality
Aquatic Toxicology Unit
1621 Mail Service Center
Raleigh, NC 27699-1621
Contact info: Cindy Moore ([e-mail]) or John Giorgino 0ohn.giorgino@ncmail. net)
D. W. Q. Form 101 (612000) 3

Facility Name: DSM Pharmaceuticals, Inc
NPDES #: NC0001058
Supplemental Metals Analysis
If copper, zinc, or chromium are present in the proposed biocidal compound, complete this worksheet. A separate form
must be used for each metal and/or metal compound present in the biocide. List the metal, its chemical formula, molecular
weight (MW), formula weight (FW), and the concentration of the metal compound in the biocide (MCC). Complete a
separate form for every metal present in the biocide.
Metal
EXAMPLE
Copper
Chemical Formula Molecular Weight of Metal Formula Weight Concentration in Biocide
CUS04.5H20 63.546 g/mole 249.680 g/mole 0.2
Dosage rate of Biocide (DR) (from page 1):
DR = grams/day
Average Daily Discharge (ADD) (from page 1):
ADD = million gallons/day
Discharge Concentration (DC) of Biocide:
DR ( grams/day)
DC = ADD = ( million gallons/day) = grams/million gallons
Convert DC to micrograms/liter (ppb):
DC (µg/1) = DC (grams/million gal) x 1 3.785 x 10610ersgm9µg/I liters/million gal.
Calculate the fraction of metal in the metal -containing compound (MF):
MF - MW - ( grams/mole) -
FW - ( grams/mole) -
Calculate the fraction of metal in the biocidal compound (BF):
BF = MF x MCC
100
x (100)
Calculate the concentration of metal in the discharge (M):
M=DCxBF=
x
Calculate the instream metal concentration (IMC) at low -flow conditions:
IMC = M x IWC (% = µg/I x 100 % - µg/I
Regulated limitation of metal (from below): Ng/I
NC General Statutes 15A NCAC 2B.0211 define:
Copper- 7 µg/I water quality action level' Zinc- 50 µg/I water quality action level'
Chromium- 50 pg/I water quality standard
(*Values which exceed action levels must be addressed directly by aquatic toxicity testing.)
D.W.Q. Form 101 (612000) 4

BIOCIDE/CHEMICAL TREATMENT
WORKSHEET-FORM 101
The following calculations are to be performed on any biocidal products ultimately discharged to the surface waters of
North Carolina. This worksheet must be completed separately for each biocidal product in use. This worksheet is to be
returned with all appropriate data entered into the designated areas with calculations performed as indicated.
Facility Name: Patheon Manufacturing Services LLC
NPDES # NC: 0001058
County: Pitt
Receiving Stream: Parker's Creek
Outfall #: 001 & 002
7Q10: 0.38 (cfs)
(All above information supplied by the Division of Water Quality)
What is the Average Daily Discharge (A.D.D.) volume of the water handling systems to the receiving water body?
A.D.D. _ .0185 (in M.G.D.)
Please calculate the Instream Waste Concentration (IWC in percent) of this discharge using the data entered
above.
IWC — (A.D.D.) X 100 _ ( ) X 100=0.02553 %
(7Q10)(0.646) + (A.D.D) - ( )(0.646) + ( )
This value (IWC) represents the waste concentration to the receiving stream during low flow conditions.
Il. What is the name of the whole product chemical treatment proposed for use in the discharge identified in Part I?
Nalco 7408
PIPacP list the active innredients and percent composition:
Active
Benefit
40% Sodium Bisulfite
Cl2 and 02 scavenger
What feed or dosage rate (D.R.) is used in this application? The units must be converted to maximum grams
of whole product used in a 24hr period.
D.R.= 1,292 grams/24hr period
Please note, fluid ounces (a volume) must be converted to grams (a mass). The formula for this conversion is:
Grams of product = fluid oz. of product X 1 gal. water X 8.34 lbs. X specific gravity of product X 453.59g.
128 fl. oz. 1 gal. water 1 lb.

Facility Name: DSM Pharmaceuticals, Inc
NPDES #: NC0001058
Estimate total volume of the water handling system between entry of biocidal product and NPDES discharge
point. On an attached sheet please provide justification for this estimate (system volume, average cycles per
blowdown, holding lagoon size, etc.)
Volume= 0.08 million gallons
What is the pH of the handling system prior to biocide addition? If unknown, enter N/A
What is the decay rate (D.K.) of the product? If unknown, assume no decay (D.K.=O) and proceed to asterisk.
The degradation must be stated at pH level within 1 /2 pH standard unit within handling system. Enter the half life
(Half Life is the time required for the initial product to degrade to half of its original concentration). Please
provide copies of the sources of this data.
H.L. = Days
The decay rate is equal to H1L X 0.69 = 0" =Decay Rate (D.K.)
Calculate degradation factor (D.F.). This is the first order loss coefficient.
" D.F. _ (Volume)
+ (D.K.) _ �---� + ( ) = 0.23
Calculate Steady State Discharge Concentration
Dischg Conc. _ (D.F.)(Volume)(3785) _ ( )( ))(3785) _ �8.55 mg/I
Calculate concentration of biocide instream during low flow conditions.
(Receiving Stream Concentration)
(Dischg. Conc.) x (IWC%) ( ) x ( ) - 0.0047 mg/I
100 = 100 -
Receiving Stream Concentration
III. Calculate regulated limitation.
List all LC50 and EC50 data available for the whole product according to the following columns. (Note that units
should be in mg/1). See SDS
D.W.Q. Form 101 (612000) 2

Facility Name: DSM Pharmaceuticals, Inc NPDES #: NC0001058
Choose the lowest LC50/EC50 listed above:
Enter the LC50/EC50: 119
If the half life (H.L.) is less than 4 days, perform the following calculation.
Regulated Limitation = 0.05 x LC50 = mg/I
If the half life (H.L.) is greater than or equal to 4 days or unknown, perform the following calculation.
Regulated Limitation = 0.01 x LC50 = 1.19 mg/I
Choose the appropriate regulated limitation from the calculations immediately above and place in this blank:
1.19 mg/liter
From Part II enter the receiving stream concentration:
0.0047 mg/liter
IV. Analysis.
If the receiving stream concentration is greater than the calculated regulated limitation, then this biocide is
unacceptable for use.
Person in Responsible Charge
Name (Print)
Signature Date
Person Completing This Worksheet (If different from above)
Name (Print)
Signature
Please submit to: Division of Water Quality
Aquatic Toxicology Unit
1621 Mail Service Center
Raleigh, NC 27699-1621
Date
Contact info: Cindy Moore ([e-mail]) or John Giorgino [e-mail])
D. W. Q. Form 101 (612000) 3

Facility Name: DSM Pharmaceuticals, Inc
NPDES #: NC0001058
Supplemental Metals Analysis
If copper, zinc, or chromium are present in the proposed biocidal compound, complete this worksheet. A separate form
must be used for each metal and/or metal compound present in the biocide. List the metal, its chemical formula, molecular
weight (MW), formula weight (FW), and the concentration of the metal compound in the biocide (MCC). Complete a
separate form for every metal present in the biocide.
Metal
EXAMPLE
Copper
Chemical Formula Molecular Weight of Metal Formula Weight Concentration in Biocide
CuSO4.5H2O 63.546 g/mole 249.680 g/mole 0.2
Dosage rate of Biocide (DR) (from page 1):
grams/day
Average Daily Discharge (ADD) (from page 1):
ADD = million gallons/day
Discharge Concentration (DC) of Biocide:
DR ( grams/day)
DC = ADD = (-million gallons/day) = grams/million gallons
Convert DC to micrograms/liter (ppb):
DC (µg/1) = DC (grams/million gal) x 1 x 106 µg/g = µg/I
3.785 x 106 liters/million gal.
Calculate the fraction of metal in the metal -containing compound (MF):
MF - MW - ( grams/mole)
FW - ( grams/mole) -
Calculate the fraction of metal in the biocidal compound (BF):
BF=MFxMCC % -
100
x (100) _
Calculate the concentration of metal in the discharge (M):
M=DCxBF=
x
Calculate the instream metal concentration (IMC) at low -flow conditions:
IMC = M x IW100% = µg/I x
°i
100 = µg/I
Regulated limitation of metal (from below): Ng/1
NC General Statutes 15A NCAC 213.0211 define:
Copper- 7 pg/I water quality action level* Zinc- 50 pg/I water quality action level*
Chromium- 50 pg/I water quality standard
(*Values which exceed action levels must be addressed directly by aquatic toxicity testing.)
D. W. Q. Form 101 (6/2000) 4

BIOCIDE/CHEMICAL TREATMENT
WORKSHEET-FORM 101
The following calculations are to be performed on any biocidal products ultimately discharged to the surface waters of
North Carolina. This worksheet must be completed separately for each biocidal product in use. This worksheet is to be
returned with all appropriate data entered into the designated areas with calculations performed as indicated.
Facility Name: Patheon Manufacturing Services LLC
NPDES # NC: 0001058
County: Pitt
Receiving Stream: Parker's Creek
Outfall #: 001 & 002
7Q10: 0.38 (cfs)
(All above information supplied by the Division of Water Quality)
What is the Average Daily Discharge (A.D.D.) volume of the water handling systems to the receiving water body?
A.D.D. _ .0185 (in M.G.D.)
Please calculate the Instream Waste Concentration (IWC in percent) of this discharge using the data entered
above.
IWC - (A.D.D.) X 100 _ ( ) X 100=0.02553 %
(7Q10)(0.646) + (A.D.D) - ( )(0.646) + ( )
This value (IWC) represents the waste concentration to the receiving stream during low flow conditions.
What is the name of the whole product chemical treatment proposed for use in the discharge identified in Part I?
3DT231
Please list the active innredients and nerrent comnosition-
Active
Function
Weight %
Phosphoric Acid Ortho Phosphate)
Mild steel corrosion inhibition
4.5% as H3PO4
Tagged High Stress Polymer THSP
Dispersant
9.0% as HSP2
Phosphinosuccinic Oligomer (PSO)
Mild steel corrosion and CaCO3 scale
inhibition
4.5% as PSO
1.4% as organic PO4
Benzotriazole BZT
Copper corrosion inhibition
1.8% as BZT
Tol Itriazole TT
Copper corrosion inhibition
0.45% as TT
What feed or dosage rate (D.R.) is used in this application? The units must be converted to maximum grams
of whole product used in a 24hr period.
D.R.= 7,91
grams/24hr period
Please note, fluid ounces (a volume) must be converted to grams (a mass). The formula for this conversion is:
Grams of product = fluid oz. of product X 1 gal. water X 8.34 lbs. X specific gravity of product X 453.59g.
128 fl. oz. 1 gal. water 1 lb.

Facility Name: DSM Pharmaceuticals, Inc
NPDES #: NC0001058
Estimate total volume of the water handling system between entry of biocidal product and NPDES discharge
point. On an attached sheet please provide justification for this estimate (system volume, average cycles per
blowdown, holding lagoon size, etc.)
Volume= 0.08
million gallons
What is the pH of the handling system prior to biocide addition? If unknown, enter N/A.
What is the decay rate (D.K.) of the product? If unknown, assume no decay (D.K.=O) and proceed to asterisk.
The degradation must be stated at pH level within 1/2 pH standard unit within handling system. Enter the half life
(Half Life is the time required for the initial product to degrade to half of its original concentration). Please
provide copies of the sources of this data.
H.L. = Days
The decay rate is equal to H1L X 0.69 = 0* =Decay Rate (D.K.)
Calculate degradation factor (D.F.). This is the first order loss coefficient.
D.F. _ (vo( .D.D.) + (D.K.) _ � � + ( ) = 0.231
Calculate Steady State Discharge Concentration:
Dischg Conc. _ (D.F.)(Vollume)(3785) _ ( )( ))(3785) = 0034 mg/I
Calculate concentration of biocide instream during low flow conditions.
(Receiving Stream Concentration)
(Dischg. Conc.) x (IWC%) ( ) x 100 100 0.00000087 mg/I
= -
Receiving Stream Concentration
III. Calculate regulated limitation.
List all LC50 and EC50 data available for the whole product according to the following columns. (Note that units
should be in mg/1). See SDS
D.W.Q. Form 101 (6/2000) 2

Facility Name: DSM Pharmaceuticals, Inc NPDES #: NC0001058
Choose the lowest LC50/EC50 listed above:
Enter the LC50/EC50: 758
If the half life (H.L.) is less than 4 days, perform the following calculation.
Regulated Limitation = 0.05 x LC50 = mg/I
If the half life (H.L.) is greater than or equal to 4 days or unknown, perform the following calculation.
Regulated Limitation = 0.01 x LC50 = 0.758 mg/I
Choose the appropriate regulated limitation from the calculations immediately above and place in this blank:
0.758 mg/liter
From Part 11 enter the receiving stream concentration:
0.00000087 mg/liter
IV. Analysis.
If the receiving stream concentration is greater than the calculated regulated limitation, then this biocide is
unacceptable for use.
Person in Responsible Charge
Name (Print)
Signature
Person Completing This Worksheet (If different from above)
Name (Print)
Signature
Please submit to: Division of Water Quality
Aquatic Toxicology Unit
1621 Mail Service Center
Raleigh, NC 27699-1621
Date
Date
Contact info: Cindy Moore ([e-mail]) or John Giorgino [e-mail])
D.W.Q. Form 101 (6/2000) 3

Facility Name: DSM Pharmaceuticals, Inc
NPDES #: NC000105
Supplemental Metals Analysis
If copper, zinc, or chromium are present in the proposed biocidal compound, complete this worksheet. A separate form
must be used for each metal and/or metal compound present in the biocide. List the metal, its chemical formula, molecular
weight (MW), formula weight (FW), and the concentration of the metal compound in the biocide (MCC). Complete a
separate form for every metal present in the biocide.
Metal Chemical Formula Molecular Weight of Metal Formula Weight Concentration in Biocide
EXAMPLE
Copper CuSO4.5H2O 63.546 g/mole 249.680 g/mole 0.2
Dosage rate of Biocide (DR) (from page 1):
DR = grams/day
Average Daily Discharge (ADD) (from page 1):
ADD = million gallons/day
Discharge Concentration (DC) of Biocide:
DR ( grams/day)
DC = ADD = (-million gallons/day) = grams/million gallons
Convert DC to micrograms/liter (ppb):
DC (µg/1) = DC (grams/million gal) x 1 x 106 µ9/9= µg/I
3.785 x 106 liters/million gal.
Calculate the fraction of metal in the metal -containing compound (MF):
MF - MW _ ( grams/mole)
FW - ( grams/mole)
Calculate the fraction of metal in the biocidal compound (BF):
MCC % %
BF = MF x 100 = x (100) _
Calculate the concentration of metal in the discharge (M):
M = DC x BF = pg/I x = µg/
Calculate the instream metal concentration (IMC) at low -flow conditions:
IMC = M x IWC (% = µg/I x 100 % - µg/I
Regulated limitation of metal (from below): _pg/I
NC General Statutes 15A NCAC 2B.0211 define:
Copper- 7 pg/I water quality action level* Zinc- 50 pg/I water quality action level*
Chromium- 50 pg/I water quality standard
(*Values which exceed action levels must be addressed directly by aquatic toxicity testing.)
D.W.Q. Form 101 (612000) 4